UBIVE hosts a research team and the National Reference Center (NRC) for Viral Hemorrhagic Fevers (VHF). Research focuses on VHF, in particular Lassa fever caused by Lassa virus, but also Ebola virus. We try to understand the molecular mechanisms involved in the pathogenesis of Lassa fever using animal and primary cell culture models. We study in particular the role of the immune response in the control of infections. We have access to several pathogenic and nonpathogenic arenaviruses thus allowing BSL-4 and BSL-2 studies. We also develop prophylactic and therapeutic approaches against Lassa fever and other arenaviruses. The NRC for VHF links fundamental research and clinical and/or field investigations. Through this activity, new viral strains and biological samples are collected. The NRC also performs applied research and surveillance and expertise activities, like the development of new tools or the study of viral diversity in the wild fauna. Notably, the NRC for FHV has been highly involved in France and on the field in Western Africa during the 2014 Ebola outbreak.
Institut Carnot Pasteur MS
The Carnot Label Carnot label is granted to public research structures, showing high level R&D competencies dedicated to fostering innovation with industrial partners. The Carnot Institutes (IC) are funded to conduct upstream research capable […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
2019Fatal Case of Lassa Fever, Bangolo District, Côte d’Ivoire, 2015, Emerging Infect. Dis. 2019 Sep;25(9):1753-1756.
2019Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses, Viruses 2019 03;11(3).
2019Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus, Viruses 2019 03;11(3).
2019Immune parameters and outcomes during Ebola virus disease, JCI Insight 2019 Jan;4(1).
2018Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells, PLoS Pathog. 2018 11;14(11):e1007430.
2018Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies, Nat Commun 2018 10;9(1):4013.
2018A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins, J. Virol. 2018 06;92(12).
2017Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs, PLoS Pathog. 2017 09;13(9):e1006610.
2017Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea, Clin. Infect. Dis. 2017 Jun;64(12):1788-1790.
2017Clinical, virological, and biological parameters associated with outcomes of Ebola virus infection in Macenta, Guinea, JCI Insight 2017 03;2(6):e88864.
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