UBIVE hosts a research team and the National Reference Center (NRC) for Viral Hemorrhagic Fevers (VHF). Research focuses on VHF, in particular Lassa fever caused by Lassa virus, but also Ebola virus. We try to understand the molecular mechanisms involved in the pathogenesis of Lassa fever using animal and primary cell culture models. We study in particular the role of the immune response in the control of infections. We have access to several pathogenic and nonpathogenic arenaviruses thus allowing BSL-4 and BSL-2 studies. We also develop prophylactic and therapeutic approaches against Lassa fever and other arenaviruses. The NRC for VHF links fundamental research and clinical and/or field investigations. Through this activity, new viral strains and biological samples are collected. The NRC also performs applied research and surveillance and expertise activities, like the development of new tools or the study of viral diversity in the wild fauna. Notably, the NRC for FHV has been highly involved in France and on the field in Western Africa during the 2014 Ebola outbreak.
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Members
Courses
MOOC Viruses and Human Cancers
The MOOC offers a broad overview of the state of knowledge on viruses associated with cancer, the different mechanisms of carcinogenesis, the host immune response and progress in preventing tumors. Registration until May 5, […]
Virus and Immunity
Virus and cellular stress
Epidemiology of Emerging Diseases
Biology of Viral Emerging Infections
Virology
Jean-Pierre Vartanian
Christian Bréchot
Francesca Di Nunzio
Daniel Scott-Algara
Antoine Gessain
Pierre-Emmanuel Ceccaldi
Hélène Laude
Pascal Pineau
Marie-Louise Michel
Hélène Strick-Marchand
Frédéric Tangy
Clementine Schilte
Odile Sismeiro
Monica Sala
Laurie Pinaud
Emerson Leonardo Alvarez Quinche
2025-05-06 09:00:00
2026-05-05 22:00:00
Europe/Paris
MOOC Viruses and Human Cancers
The MOOC offers a broad overview of the state of knowledge on viruses associated with cancer, the different mechanisms of carcinogenesis, the host immune response and progress in preventing tumors. Registration until May 5, […]
Institut Pasteur, Rue du Docteur Roux, Paris, France
Projects
Transversal Project
Fundings
Publications
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2025Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever, PLoS Pathogens, 2025, 21 (4), pp.e1013111. ⟨10.1371/journal.ppat.1013111⟩.
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2024Fatal Lassa fever in cynomolgus monkeys is associated with systemic viral dissemination and inflammation., PLoS Pathog 2024 Dec; 20(12): e1012768.
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2024Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein., PLoS Pathog 2024 Dec; 20(12): e1012715.
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2024High seroreactivities to orthoebolaviruses in rural Cameroon: a case-control study on non-human primate bites and a cross-sectional survey in rural population, Journal of Infectious Diseases, 2024, pp.jiae399. ⟨10.1093/infdis/jiae399⟩.
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2023Novel Antiviral Molecules against Ebola Virus Infection., Int J Mol Sci 2023 Sep; 24(19): .
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2023Hemostasis defects underlying the hemorrhagic syndrome caused by Mammarenaviruses in a cynomolgus macaque model., Blood 2023 Sep; (): .
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2023Immunogenicity, safety, and tolerability of a recombinant measles-vectored Lassa fever vaccine: a randomised, placebo-controlled, first-in-human trial, 2023 Apr 15;401(10384):1267-1276. doi: 10.1016/S0140-6736(23)00048-X. Epub 2023 Mar 16. .
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2023Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys., Nat Commun 2023 Mar; 14(1): 1352.
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2023A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates., Nat Microbiol 2023 Jan; 8(1): 64-76.
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2022Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys., Virulence 2022 12; 13(1): 654-669.
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Contact
Phone: + 33 4 37 28 24 40 Email: sylvain.baize@pasteur.fr Address 21 avenue Tony Garnier, 69007 LYON France