Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
03
Jul 2015
Status
Ongoing
Members
4
Structures
1

About

 

Research in this area is strongly linked to the activities of the National Influenza Reference Center (NIC) and WHO Reference Laboratory for H5 and SARS-CoV viruses, associated to the unit. We contribute to the epidemiological and virological surveillance of human influenza viruses and of other respiratory viruses at the national, European and international level. In case of emergence of a new respiratory virus, such as the H1N1pdm09 influenza virus in 2009, or of sporadic human cases of infection with a zoonotic virus, such as the highly pathogenic H5N1 influenza viruses since 2003, the H7N9 influenza virus in 2013 or the MERS coronavirus since 2012, we develop appropriate methods for the detection, and genetic, antigenic and phenotypic characterization of the emerging virus, as well as serological tools.

We are working in close collaboration with clinicians. During the H1N1pdm09 pandemic, we contributed to the description of the kinetics of virus excretion and to the characterization of severe cases from a virological and an immunological point of view. More recently, we contributed to the investigations on two cases of MERS-CoV infection in France.

Our studies on influenza virus evolution are aimed at understanding the drivers underlying genetic diversity through isolation of fidelity variants of the viral polymerase and evaluation of the diversity of the viral populations in link with influenza virus (sub)-types, species origin and clinical severity. They are also focused on the mechanisms that favor the emergence of viruses with reduced susceptibility to antiviral treatments. Studies on the role of the non-coding (NC) extremities of the viral RNA in the regulation of expression of the viral genomic segments and type-specificity of influenza type A and type C viruses further provide insights into the limitations of reassortment, another major driver of evolution of influenza viruses.

 

Keywords : influenza virus, MERS-CoV, viral diagnosis, viral evolution, genetic diversity, genetic reassortment, resistance to antivirals