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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Department Manager
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
12
Jun 2020
Ending Date
11
Dec 2021
Status
Ongoing
Members
5
Structures
4

About

Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2
virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is
designed to target the priority of “pathophysiology of the disease” through the following objectives
1. To develop a cellular model to study human-viral interactions on the adaptive immune response
2. To dissect of how antigen-presenting cells (APCs) polarize T cell responses leading to over-reactive
immunological reaction and/or protective memory T cells
3. To investigate the role of regulatory T cell (Treg) in regulating immune responses
4. To identify CD4+ T cell epitopes of SARS-CoV-2 presented by APCs and validation of these
epitopes in patients recovered from COVID-19
5. To explore underlying immune mechanisms predisposing patients with diabetes and cardiovascular
diseases to severe COVID-19

Fundings