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© K. Stapleford, M. Vignuzzi, I. Bonne, C. Schmitt, J-M. Panaud
Chikungunya virus emerging from infected C6/36 mosquito cells (Aedes albopictus)
Publication : Emerging infectious diseases

Vaccine-Derived Polioviruses, Central African Republic, 2019.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Emerging infectious diseases - 01 Feb 2021

Joffret ML, Doté JW, Gumede N, Vignuzzi M, Bessaud M, Gouandjika-Vasilache I,

Link to Pubmed [PMID] – 33496226

Link to DOI – 10.3201/eid2702.203173

Emerg Infect Dis 2021 Feb; 27(2): 620-623

Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations (<20) in the viral capsid protein 1-encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably <3 years) before being isolated. Environmental surveillance, which relies on a limited number of sampling sites in the Central African Republic and does not cover the whole country, failed to detect the circulation of VDPV-2s before some had induced poliomyelitis in children.

https://pubmed.ncbi.nlm.nih.gov/33496226