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© Research
Publication : Cell host & microbe

Manipulating Mosquito Tolerance for Arbovirus Control

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell host & microbe - 11 Sep 2019

Lambrechts L, Saleh MC

Link to Pubmed [PMID] – 31513769

Cell Host Microbe 2019 09;26(3):309-313

The inexorable emergence of mosquito-borne arboviruses and the failure of traditional vector control methods to prevent their transmission have triggered the development of alternative entomological interventions to render mosquito populations incapable of carrying arboviruses. Here, we use a theoretical framework to argue that decreasing mosquito tolerance to arbovirus infection could be a more evolutionarily sustainable disease control strategy than increasing mosquito resistance. Increasing resistance is predicted to select for mutant arboviruses escaping resistance, whereas reducing tolerance should lead to the death of infected vectors and thus select for mosquito-attenuated arbovirus variants that are less transmissible.

https://www.ncbi.nlm.nih.gov/pubmed/31513769