Timeline
Roland Brosch
Head of Structure
01 Mar 2024
01 Jul 2023
publication
Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli.
Read more07 Dec 2022
publication
Author Correction: A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome.
Read more18 Nov 2022
publication
A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome.
Read more14 Sep 2022
publication
A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity.
Read more26 Jul 2022
publication
A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity.
Read more15 Mar 2022
publication
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence.
Read more08 Mar 2022
publication
The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy.
Read more01 Jan 2022
publication
The MtZ Strain: Molecular Characteristics and Outbreak Investigation of the Most Successful Mycobacterium tuberculosis Strain in Aragon Using Whole-Genome Sequencing.
Read more23 Nov 2021
01 Aug 2021
publication
Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli.
Read more30 Jul 2021
publication
Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.
Read more18 May 2021
publication
ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains
Read more05 May 2021
publication
IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo.
Read more15 Apr 2021
01 Feb 2021
publication
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts.
Read more25 Aug 2020
publication
Mucosal delivery of ESX-1-expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes.
Read more01 Aug 2020
publication
Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors.
Read more04 May 2020
publication
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Read more28 Apr 2020
publication
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential
Read more04 Mar 2020
publication
A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies
Read more11 Feb 2020
07 Feb 2020
publication
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis
Read more04 Feb 2020
publication
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
Read more28 Nov 2019
08 Nov 2019
publication
Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages
Read more01 Aug 2019
publication
Shared pathogenomic patterns characterize a new phylotype, revealing transition towards host-adaptation long before speciation of Mycobacterium tuberculosis
Read more01 Jul 2019
publication
ESX/Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins
Read more01 Mar 2019
publication
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers Against Tuberculosis
Read more06 Feb 2019
10 Dec 2018
publication
Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria.
Read more19 Nov 2018
publication
[The most ancestral mycobacterial ESX-4 secretion system is essential for intracellular growth of Mycobacterium abscessus within environmental and human phagocytes]
Read more11 Jul 2018
publication
Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity
Read more18 Jun 2018
publication
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
Read more24 Apr 2018
publication
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors
Read more17 Jan 2018
publication
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
Read more15 Jan 2018
publication
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis
Read more04 Dec 2017
27 Nov 2017
publication
Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation
Read more23 Nov 2017
publication
The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis
Read more08 Nov 2017
04 Oct 2017
publication
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development
Read more26 Sep 2017
publication
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling
Read more28 Aug 2017
18 Jul 2017
publication
Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells
Read more14 Jul 2017
publication
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles
Read more17 May 2017
publication
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Read more14 Mar 2017
publication
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection
Read more15 Feb 2017
publication
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis
Read more01 Feb 2017
publication
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis
Read more24 Jan 2017
publication
Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions
Read more17 Jan 2017
publication
Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384
Read more01 Jan 2017
publication
Subcellular localization of M. tuberculosis in vivo and effect of the adaptive immunity
Read more16 Nov 2016
11 Nov 2016
01 Nov 2016
publication
The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages
Read more01 Oct 2016
publication
Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance
Read more26 Sep 2016
26 Sep 2016
15 Aug 2016
publication
Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria
Read more28 Jul 2016
publication
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection
Read more21 Jul 2016
24 Jun 2016
publication
Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’
Read more31 May 2016
publication
Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access
Read more28 Apr 2016
publication
A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus
Read more28 Apr 2016
publication
A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts
Read more25 Apr 2016
publication
ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo
Read more17 Feb 2016
publication
Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications
Read more01 Feb 2016
27 Jan 2016
publication
pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence
Read more20 Jan 2016
08 Jan 2016
publication
Mycobacterial pan-genome analysis suggests important role of plasmids in the radiation of type VII secretion systems
Read more07 Jan 2016
18 Dec 2015
publication
Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members
Read more02 Dec 2015
25 Nov 2015
publication
Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions
Read more25 Nov 2015
publication
Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis
Read more05 Nov 2015
publication
The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis
Read more21 Oct 2015
publication
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations
Read more10 Jun 2015
publication
Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity
Read more11 May 2015
11 Apr 2015
publication
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system
Read more04 Mar 2015
publication
[Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans]
Read more01 Mar 2015
25 Feb 2015
publication
Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii
Read more13 Feb 2015
publication
ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection
Read more06 Feb 2015
publication
Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo
Read more08 Dec 2014
publication
Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice
Read more03 Aug 2014
publication
A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent
Read more21 Jul 2014
publication
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator
Read more02 Jun 2014
publication
A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component
Read more20 Feb 2014
publication
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection
Read more01 Feb 2014
01 Jan 2014
publication
Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs
Read more01 Jan 2014
publication
Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development
Read more17 Sep 2013
publication
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus
Read more02 Aug 2013
publication
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis
Read more12 Jun 2013
publication
Single cell measurements of vacuolar rupture caused by intracellular pathogens
Read more01 Mar 2013
16 Jan 2013
06 Jan 2013
publication
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis
Read more17 Dec 2012
publication
The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability
Read more13 Aug 2012
publication
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
Read more11 Jul 2012
publication
Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh
Read more08 May 2012
publication
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria
Read more19 Apr 2012
publication
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential
Read more01 Apr 2012
publication
Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies
Read more20 Feb 2012
publication
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation
Read more02 Feb 2012
publication
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death
Read more01 Jan 2012
20 Dec 2011
publication
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis
Read more15 Apr 2011
publication
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis
Read more20 Jan 2011
publication
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237
Read more05 Jan 2011
publication
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants
Read more01 Oct 2010
publication
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring
Read more09 Sep 2010
publication
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
Read more10 Apr 2010
publication
Drug-resistant tuberculosis in the European Union: opportunities and challenges for control
Read more30 Oct 2009
publication
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors
Read more30 Oct 2009
19 Aug 2009
01 Aug 2009
07 Jul 2009
publication
Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families
Read more19 Jun 2009
publication
Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus
Read more01 Jun 2009
publication
Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis
Read more01 Apr 2009
publication
Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants
Read more19 Mar 2009
publication
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
Read more18 Jan 2009
01 Dec 2008
publication
Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism
Read more10 Apr 2008
publication
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
Read more01 Feb 2008
publication
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
Read more08 Jun 2007
publication
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity
Read more01 May 2007
19 Mar 2007
01 Sep 2006
06 Mar 2006
publication
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis
Read more01 Jan 2006
publication
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
Read more19 Aug 2005
publication
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis
Read more01 Aug 2005
01 Aug 2005
publication
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin
Read more27 Jul 2005
publication
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity
Read more10 May 2005
publication
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress
Read more15 Mar 2005
publication
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system
Read more01 Mar 2005
publication
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans
Read more01 Nov 2004
04 Jun 2004
publication
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens
Read more01 Apr 2004
publication
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
Read more01 Feb 2004
publication
Macro-array and bioinformatic analyses reveal mycobacterial ‘core’ genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex
Read more01 Feb 2004
publication
Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain
Read more21 Jan 2004
publication
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans
Read more01 Jan 2004
publication
[Use of the mycobacteria genome to develop new vaccines and therapeutic targets]
Read more14 Apr 2003
publication
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
Read more01 Mar 2003
publication
Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex?
Read more01 Nov 2002
publication
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
Read more01 Oct 2002
publication
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant
Read more01 Jul 2002
publication
Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis
Read more12 Mar 2002
01 Jan 2002
publication
Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics
Read more01 Sep 2001
01 Jan 2001
01 Dec 2000
30 Jun 2000
publication
Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur
Read more01 May 2000
01 Mar 2000
01 Nov 1999
publication
Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain
Read more01 May 1999
publication
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays
Read more01 Jan 1999
01 Dec 1998
publication
The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes
Read more11 Jun 1998
publication
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Read more01 May 1998
publication
Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics
Read more01 Feb 1997
publication
Genomic analyses of Salmonella enteritidis phage type 4 strains from Austria and phage type 8 strains from the United States
Read more01 Oct 1996
publication
Genomic fingerprinting of 80 strains from the WHO multicenter international typing study of listeria monocytogenes via pulsed-field gel electrophoresis (PFGE)
Read more01 May 1996
publication
Prevalence and clonal nature of Escherichia coli O157:H7 on dairy farms in Wisconsin
Read more01 Feb 1996
publication
Genomic analysis using pulsed-field gel electrophoresis of Escherichia coli O157: H7 isolated from dairy calves during the United State National Dairy Heifer Evaluation Project (1992-1992)
Read more01 Aug 1995
publication
Use of pulsed-field gel electrophoresis to link sporadic cases of invasive listeriosis with recalled chocolate milk
Read more01 Jun 1995
publication
Investigations related to the epidemic strain involved in the French listeriosis outbreak in 1992
Read more01 Jul 1994
publication
Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar
Read more01 Dec 1993
publication
Isolation and characterization of Listeria monocytogenes-specific nucleotide sequences
Read more01 Apr 1993
publication
Pulsed-field gel electrophoresis applied for comparing Listeria monocytogenes strains involved in outbreaks
Read more01 Apr 1993
01 Jan 1992
01 Dec 1991
publication
Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3
Read more01 Oct 1991
publication
Use of pulsed field electrophoresis of DNA restriction fragments for comparing Listeria monocytogenes strains isolated from human infections and food in Austria
Read more01 Jul 1991
publication
Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis
Read more01 Jan 1989
publication
On the drinking water situation on the Cape Verde Islands (Island of Santiago)
Read more01 Jan 1989
01 Jan 1988
publication
Serological investigations in Q-fever and listeriosis of wild-living small mammals on the Cape Verde Islands
Read more01 Jan 1988
publication
Serological investigations for antibodies against Treponema pallidum on the Cape Verde Islands (Santiago and Santo Antao)–2. report
Read more01 Jan 1987