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© Research
Publication : Trends in microbiology

ESAT-6 proteins: protective antigens and virulence factors?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in microbiology - 01 Nov 2004

Brodin P, Rosenkrands I, Andersen P, Cole ST, Brosch R

Link to Pubmed [PMID] – 15488391

Trends Microbiol. 2004 Nov;12(11):500-8

The 6kDa early secreted antigenic target from Mycobacterium tuberculosis, ESAT-6, is the prototype of a novel family of small proteins of unknown function produced by Actinobacteria. Export of ESAT-6, a potent T-cell antigen, and related proteins requires a dedicated secretory apparatus that is encoded by a cluster of genes, several of which also code for proteins that are recognized strongly by T cells. ESAT-6 systems can thus be considered as immunogenicity islands and there is growing evidence that the corresponding genes are subject to selective pressure imposed by the immune system of the host. Recently, there has been major progress in understanding the biogenesis, secretion and antigenicity of ESAT-6 proteins and, at least in the case of ESAT-6 system 1, in unravelling their role in pathogenicity. Here, we discuss these findings and their implications for the development of new therapeutic and prophylactic interventions against tuberculosis.

http://www.ncbi.nlm.nih.gov/pubmed/15488391