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© Research
Publication : Cell host & microbe

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell host & microbe - 10 Jun 2015

Majlessi L, Brosch R

Link to Pubmed [PMID] – 26067600

Cell Host Microbe 2015 Jun;17(6):733-5

The intracellular fate of Mycobacterium tuberculosis is a subject of long debate. In this issue of Cell Host & Microbe, three independent studies reveal the detection of cytosolic mycobacterial DNA by the nucleotidyltransferase cGAS, emphasizing the concept of cytosolic access by M. tuberculosis and its role in balancing immune-protection and immune-pathogenesis.

http://www.ncbi.nlm.nih.gov/pubmed/26067600