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© Research
Publication : The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 01 Jan 2012

Banu S, Uddin MK, Islam MR, Zaman K, Ahmed T, Talukder AH, Rahman MT, Rahim Z, Akter N, Khatun R, Brosch R, Endtz HP

Link to Pubmed [PMID] – 22640444

Int. J. Tuberc. Lung Dis. 2012;16(3):319-26

OBJECTIVE: To characterise and classify clinical isolates collected from tuberculosis (TB) patients in rural Bangladesh and to investigate the mode of transmission.

DESIGN: An epidemiological study using a combination of conventional and molecular methods was performed in a rural population of Bangladesh. A total of 168 clinical isolates were collected from TB patients. Deletion analysis, used for rapid differentiation of members of the Mycobacterium tuberculosis complex, spoligotyping and variable number tandem repeats of mycobacterial interspersed repetitive units (VNTR-MIRU) typing were used.

RESULTS: Deletion analysis identified all isolates as M. tuberculosis and further divided them into 109 strains (65%) carrying the M. tuberculosis deletion region 1 (TbD1-intact or ‘ancestral’ strains) and 59 strains (35%) lacking this region (TbD1 or ‘modern’ strains). MIRU analyses showed that 149 strains (89%) had unique patterns, whereas 19 strains (11%) clustered into eight groups. The largest cluster comprised five TbD1 strains of the Beijing type. The rate of recent transmission was estimated to be 6.5%.

CONCLUSIONS: Our results suggest that TB in rural Bangladesh is caused primarily by reactivation of latent infections involving TbD1 intact strains, overlaid with the recent emergence of Beijing strain clusters that include multidrug-resistant isolates.

http://www.ncbi.nlm.nih.gov/pubmed/22640444