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© Research
Publication : Cellular microbiology

Breaching the phagosome, the case of the tuberculosis agent.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular microbiology - 15 Apr 2021

Simeone R, Sayes F, Lawarée E, Brosch R,

Link to Pubmed [PMID] – 33860624

Link to DOI – 10.1111/cmi.13344

Cell Microbiol 2021 Apr; (): e13344

The interactions between microbes and their hosts are among the most complex biological phenomena known today. The interaction may reach from overall beneficial interaction, as observed for most microbiome/microbiota related interactions to interaction with virulent pathogens, against which host cells have evolved sophisticated defence strategies. Among the latter, the confinement of invading pathogens in a phagosome plays a key role, which often results in the destruction of the invader, whereas some pathogens may counteract phagosomal arrest and survive by gaining access to the cytosol of the host cell. In the current review, we will discuss recent insights into this dynamic process of host-pathogen interaction, using Mycobacterium tuberculosis and related pathogenic mycobacteria as main examples.

https://pubmed.ncbi.nlm.nih.gov/33860624