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© Research
Publication : Current opinion in microbiology

ESX/type VII secretion systems and their role in host-pathogen interaction

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 18 Jan 2009

Simeone R, Bottai D, Brosch R

Link to Pubmed [PMID] – 19155186

Curr. Opin. Microbiol. 2009 Feb;12(1):4-10

The ESX-1 system is responsible for the secretion of the prototypic ESX proteins, namely the 6 kDa early secreted antigenic target (ESAT-6) and the 10 kDa culture filtrate protein (CFP-10). These two proteins, which form a 1:1 heterodimeric complex, are among the most important proteins of Mycobacterium tuberculosis involved in host-pathogen interaction. They induce a strong T cell mediated immune response, are apparently involved in membrane and/or host-cell lysis and represent key virulence factors. There are four other paralogous ESX systems in M. tuberculosis, some of which are essential for in vitro growth. ESX systems also exist in many other actinobacteria and Gram-positive bacteria, and have recently been suggested to be named type VII secretion systems.

http://www.ncbi.nlm.nih.gov/pubmed/19155186