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© Research
Publication : Current pharmaceutical design

Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current pharmaceutical design - 01 Jan 2014

Bottai D, Serafini A, Cascioferro A, Brosch R, Manganelli R

Link to Pubmed [PMID] – 24245757

Curr. Pharm. Des. 2014;20(27):4346-56

The emergence of multi- and extensively-drug resistant strains of Mycobacterium tuberculosis makes the development of novel anti-tubercular compounds and the identification of alternative mycobacterial drugable targets urgent priorities. Recently, type VII secretion systems (T7SS) have been discovered in mycobacteria. The genome of M. tuberculosis encodes 5 of such systems (ESX-1 to -5), three of which have been characterized and shown to be essential for viability (ESX-3, ESX-5) or virulence (ESX-1, ESX-5). Because of their crucial role in host-pathogen interactions as well as their involvement in basic biological processes of tubercle bacilli, T7SS/ESX represent promising targets for novel anti-tuberculosis drugs. Here, we review the current knowledge of the T7SS/ESX and their impact on M. tuberculosis physiology and virulence. Finally, we discuss the possible approaches to develop T7SS/ESX inhibitors.

http://www.ncbi.nlm.nih.gov/pubmed/24245757