Timeline

Roland Brosch
Head of Structure
01 Aug 2019
publication

Shared pathogenomic patterns characterize a new phylotype, revealing transition towards host-adaptation long before speciation of Mycobacterium tuberculosis

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01 Jul 2019
publication

ESX/Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins

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01 Mar 2019
publication

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers Against Tuberculosis

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06 Feb 2019
news

Award: Roland BROSCH elected as a new Fellow of the American Academy of Microbiology

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10 Dec 2018
publication

Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria

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19 Nov 2018
publication

[The most ancestral mycobacterial ESX-4 secretion system is essential for intracellular growth of Mycobacterium abscessus within environmental and human phagocytes]

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26 Sep 2018
publication

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach

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11 Jul 2018
publication

Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity

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18 Jun 2018
publication

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

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24 Apr 2018
publication

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

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17 Jan 2018
publication

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

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15 Jan 2018
publication

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

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04 Dec 2017
publication

Evolution of virulence in the Mycobacterium tuberculosis complex

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27 Nov 2017
publication

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation

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23 Nov 2017
publication

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

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08 Nov 2017
publication

The Biology and Epidemiology of Mycobacterium canettii

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04 Oct 2017
publication

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

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26 Sep 2017
publication

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

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28 Aug 2017
publication

Un nouveau concept pour améliorer le vaccin antituberculeux

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18 Jul 2017
publication

Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells

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14 Jul 2017
publication

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

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17 May 2017
publication

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

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14 Mar 2017
publication

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

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15 Feb 2017
publication

ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

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01 Feb 2017
publication

Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis

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24 Jan 2017
publication

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

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17 Jan 2017
publication

Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384

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01 Jan 2017
publication

Subcellular localization of M. tuberculosis in vivo and effect of the adaptive immunity

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16 Nov 2016
publication

Discovery of the type VII ESX-1 secretion needle ?

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11 Nov 2016
publication

Leprosy in red squirrels

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01 Nov 2016
publication

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages

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01 Oct 2016
publication

Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance

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26 Sep 2016
project

PreDiCT-TB

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26 Sep 2016
publication

ESX secretion systems: mycobacterial evolution to counter host immunity

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15 Aug 2016
publication

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

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28 Jul 2016
publication

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

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21 Jul 2016
project

TBVAC 2020

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24 Jun 2016
publication

Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’

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31 May 2016
publication

Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access

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28 Apr 2016
publication

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus

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28 Apr 2016
publication

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts

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25 Apr 2016
publication

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo

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17 Feb 2016
publication

Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications

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01 Feb 2016
publication

The BCG Strain Pool: Diversity Matters

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27 Jan 2016
publication

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

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20 Jan 2016
project

MM4TB

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08 Jan 2016
publication

Mycobacterial pan-genome analysis suggests important role of plasmids in the radiation of type VII secretion systems

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07 Jan 2016
publication

Type VII Secretion Systems in Gram-Positive Bacteria

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18 Dec 2015
publication

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members

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02 Dec 2015
event

EMBO Conference Tuberculosis 2016

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25 Nov 2015
publication

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions

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25 Nov 2015
publication

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

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05 Nov 2015
publication

The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis

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21 Oct 2015
publication

Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations

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10 Jun 2015
publication

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

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11 May 2015
team

Integrated Mycobacterial Pathogenomics

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11 Apr 2015
publication

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system

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04 Mar 2015
publication

[Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans]

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01 Mar 2015
publication

Release of mycobacterial antigens

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25 Feb 2015
publication

Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii

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13 Feb 2015
publication

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

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06 Feb 2015
publication

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo

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08 Dec 2014
publication

Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice

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03 Aug 2014
publication

A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent

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21 Jul 2014
publication

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

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02 Jun 2014
publication

A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component

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20 Feb 2014
publication

Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

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01 Feb 2014
publication

Mycobacterial Pathogenomics and Evolution

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01 Jan 2014
publication

Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs

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01 Jan 2014
publication

Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development

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17 Sep 2013
publication

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus

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02 Aug 2013
publication

ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis

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12 Jun 2013
publication

Single cell measurements of vacuolar rupture caused by intracellular pathogens

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01 Mar 2013
publication

Characterization of Mycobacterium orygis

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16 Jan 2013
publication

TBCAP; tuberculosis annotation project

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06 Jan 2013
publication

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

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17 Dec 2012
publication

The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability

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13 Aug 2012
publication

ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells

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11 Jul 2012
publication

Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh

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08 May 2012
publication

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

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19 Apr 2012
publication

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential

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01 Apr 2012
publication

Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies

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20 Feb 2012
publication

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

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02 Feb 2012
publication

Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death

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01 Jan 2012
publication

Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh

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20 Dec 2011
publication

Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis

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06 Jun 2011
publication

p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways

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15 Apr 2011
publication

ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis

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20 Jan 2011
publication

Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237

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05 Jan 2011
publication

Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants

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18 Nov 2010
publication

Entrapment of intracytosolic bacteria by septin cage-like structures

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01 Oct 2010
publication

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring

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09 Sep 2010
publication

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling

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10 Apr 2010
publication

Drug-resistant tuberculosis in the European Union: opportunities and challenges for control

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30 Oct 2009
publication

High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors

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30 Oct 2009
publication

Systematic genetic nomenclature for type VII secretion systems

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19 Aug 2009
publication

Pathogenomics of mycobacteria

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01 Aug 2009
publication

[A promising new class of antituberculous molecules]

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07 Jul 2009
publication

Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families

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19 Jun 2009
publication

Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus

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01 Jun 2009
publication

Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis

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01 Apr 2009
publication

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

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19 Mar 2009
publication

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

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18 Jan 2009
publication

ESX/type VII secretion systems and their role in host-pathogen interaction

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01 Dec 2008
publication

Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism

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10 Apr 2008
publication

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

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01 Feb 2008
publication

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

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08 Jun 2007
publication

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

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01 May 2007
publication

Cutting-edge science and the future of tuberculosis control

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19 Mar 2007
publication

Genome plasticity of BCG and impact on vaccine efficacy

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01 Sep 2006
publication

“A re-evaluation of M. prototuberculosis”: continuing the debate

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06 Mar 2006
publication

Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis

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01 Jan 2006
publication

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence

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19 Aug 2005
publication

Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis

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01 Aug 2005
publication

Tuberculosis: from genome to vaccine

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01 Aug 2005
publication

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin

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27 Jul 2005
publication

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity

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10 May 2005
publication

Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

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15 Mar 2005
publication

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system

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01 Mar 2005
publication

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans

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01 Nov 2004
publication

ESAT-6 proteins: protective antigens and virulence factors?

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04 Jun 2004
publication

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens

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01 Apr 2004
publication

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6

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01 Feb 2004
publication

Macro-array and bioinformatic analyses reveal mycobacterial ‘core’ genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex

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01 Feb 2004
publication

Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain

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21 Jan 2004
publication

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

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01 Jan 2004
publication

[Use of the mycobacteria genome to develop new vaccines and therapeutic targets]

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14 Apr 2003
publication

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

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01 Mar 2003
publication

Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex?

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01 Nov 2002
publication

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

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01 Oct 2002
publication

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant

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01 Jul 2002
publication

Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis

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12 Mar 2002
publication

A new evolutionary scenario for the Mycobacterium tuberculosis complex

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01 Jan 2002
publication

Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics

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01 Sep 2001
publication

The evolution of mycobacterial pathogenicity: clues from comparative genomics

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01 Jan 2001
publication

Genomics of Mycobacterium bovis

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01 Dec 2000
publication

Tools for the population genomics of the tubercle bacilli

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30 Jun 2000
publication

Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur

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01 May 2000
publication

Comparative genomics of the mycobacteria

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01 Mar 2000
publication

Comparative genomics of the leprosy and tubercle bacilli

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01 Nov 1999
publication

Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain

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01 May 1999
publication

Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays

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01 Jan 1999
publication

Analysis of the proteome of Mycobacterium tuberculosis in silico

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01 Dec 1998
publication

The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes

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11 Jun 1998
publication

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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01 May 1998
publication

Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics

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01 Feb 1997
publication

Genomic analyses of Salmonella enteritidis phage type 4 strains from Austria and phage type 8 strains from the United States

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01 Oct 1996
publication

Genomic fingerprinting of 80 strains from the WHO multicenter international typing study of listeria monocytogenes via pulsed-field gel electrophoresis (PFGE)

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01 May 1996
publication

Prevalence and clonal nature of Escherichia coli O157:H7 on dairy farms in Wisconsin

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01 Feb 1996
publication

Genomic analysis using pulsed-field gel electrophoresis of Escherichia coli O157: H7 isolated from dairy calves during the United State National Dairy Heifer Evaluation Project (1992-1992)

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01 Aug 1995
publication

Use of pulsed-field gel electrophoresis to link sporadic cases of invasive listeriosis with recalled chocolate milk

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01 Jun 1995
publication

Investigations related to the epidemic strain involved in the French listeriosis outbreak in 1992

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01 Jul 1994
publication

Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar

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01 Dec 1993
publication

Isolation and characterization of Listeria monocytogenes-specific nucleotide sequences

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01 Apr 1993
publication

Pulsed-field gel electrophoresis applied for comparing Listeria monocytogenes strains involved in outbreaks

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01 Apr 1993
publication

Characterization of Listeria strains isolated from soft cheese

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01 Jan 1992
publication

[10 years foodborne listeriosis–an evaluation]

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01 Dec 1991
publication

Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3

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01 Oct 1991
publication

Use of pulsed field electrophoresis of DNA restriction fragments for comparing Listeria monocytogenes strains isolated from human infections and food in Austria

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01 Jul 1991
publication

Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis

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01 Jan 1989
publication

On the drinking water situation on the Cape Verde Islands (Island of Santiago)

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01 Jan 1989
publication

A survey of leptospirological studies carried out on the Cape Verde Islands

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01 Jan 1988
publication

Serological investigations in Q-fever and listeriosis of wild-living small mammals on the Cape Verde Islands

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01 Jan 1988
publication

Serological investigations for antibodies against Treponema pallidum on the Cape Verde Islands (Santiago and Santo Antao)–2. report

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01 Jan 1987
publication

Resistance to antibiotics in humans and animals on the Cape Verde Islands

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