Odile Sismeiro is holding a “Diplôme Universitaire de Technologie” and a “Diplôme d’Etudes Scientifiques et Techniques” (Conservatoire des Arts et Métiers, CNAM, Paris). She joined the Institut Pasteur in 1987 and worked for 13 years on the regulation of genetic expression in bacteria in Antoine Danchin’s research unit. She then joined the PF2 platform. She firstly contributed to the development of the DNA array technology at the platform and, in 2009, she established Next Generation Sequencing. Since then, as engineer, she conducted many projects aiming at gene expression profiling, from the quality control of the nucleic acids to the generation of sequencing data. She also has important user training and technological development activities. She is also taking a very active part in communication.
Multiple roles of RNAs
A practical course on RNA methods RNA research is at the basis of our current understanding of gene expression regulation and was crucial for the discovery of tools such as siRNA and CRISPR/Cas9. RNA […]
Workshop: Bacterial RNAseq
We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
Training: analysis of the transcriptome by RNAseq
The Transcriptome and Epigenome platform of the Biomics pole is organizing a one week (October 10, 2016 – October 14, 2016) training session dedicated to the analysis of the transcriptome by RNAseq. It is […]
Insights into amebiasis using a human 3D-intestinal model (ANR-14-IFEC-0001-02)
This project is a part of the international Infect-Era program, AMOEBAC: Entamoeba histolytica-bacterium interaction and the role of this interaction in intestinal pathogenesis (http://www.infect-era.eu/2nd-call-2014) The aim of this investigation is to understand the induced […]
Understanding the Pathogenicity of Entamoeba Using Comparative Transcriptomics and Phylogenomics – GENAMIBE. Project-ANR-10-GENM-0011
Entamoeba histolytica is a protozoan parasite and an amitochondriate pathogenic amoeba, which may cause dysentery and liver abscess in humans (i.e. amoebiasis). Differential pathogenicity is observed among E. histolytica strains: strain HM1:IMSS is virulent […]
Deciphering the virulence factors of Mycobacterium abscessus activated in the presence of environmental amoebae
Mycobacterium abscessus (M. abs) is an emerging pathogen causing lung infections in cystic fibrosis patients. Although the environmental reservoir of M. abs is currently unknown, M. abs possesses a gene pool dedicated to a […]
The role of lncRNA H19 in Thymopoiesis
“The thymus is a specialized organ that provides a unique environment for T cell development and differentiation. The study the thymus-settling progenitors (TSPs) and how they differentiate is important for the characterization of the […]
Intracellular membrane proliferation in E. coli
Overproduction of membrane proteins in the E. coli strains generally induce cell death. The multiple mutant C43 (DE3) derivative of BL21 (DE3) strain was selected to resist this overproduction. In this mutant, the membrane […]
HIV signature on RIG-I-like receptors
The pathogenesis of HIV infection, and in particular the development of immunodeficiency, remains incompletely understood. During HIV infection both innate and adaptive immune responses are raised, but they appear to be insufficient or too […]
Biostatistics for data analysis
The platform provides statistical analyses of RNA-seq count data. Before any project starts, we help the user to design his experiment in order to ensure that it really addresses the biological question he wishes […]
2022The gut environment regulates bacterial gene expression which modulates susceptibility to bacteriophage infection., Cell Host Microbe 2022 Apr; 30(4): 556-569.e5.
2022Trained ILC3 responses promote intestinal defense., Science 2022 Feb; 375(6583): 859-863.
2022Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation., Proc Natl Acad Sci U S A 2022 02; 119(7):e2111228119. doi: 10.1073/pnas.2111228119. .
2021Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness., Mol Ecol 2021 Dec; (): .
2021The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence., PLoS Pathog 2021 Dec; 17(12): e1009087.
2021Sleeping ribosomes: Bacterial signaling triggers RaiA mediated persistence to aminoglycosides., iScience 2021 Oct; 24(10): 103128.
2021Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira., Mol Microbiol 2021 Oct; (): .
2021The CovR regulatory network drives the evolution of Group B Streptococcus virulence., PLoS Genet 2021 Sep; 17(9): e1009761.
2021Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus., mBio 2021 May; 12(3): .
2021Yolk sac, but not hematopoietic stem cell-derived progenitors, sustain erythropoiesis throughout murine embryonic life., J Exp Med 2021 Apr; 218(4): .
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