Grand Programme Fédérateur Vaccinologie
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Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.
The purpose of this call for ideas is to solicit community input for original, cutting-edge science investigations that are consistent with the Institut Pasteur’s new development strategy in vaccinology. The “Open Pasteur vaccine challenge” […]
GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates
With the second call, the GPF Vaccinology aims at identifying ongoing preclinical projects aiming to develop vaccine candidates at Institut Pasteur, including the International Network. The objective of the GPF call is to help […]
Comics on vaccination
The Center for Translational Science, the Center Medical Institut Pasteur (CMIP) and the major federating program (GPF) vaccinology welcome for one year a science illustrator, Celia Ducaju, in partnership with the Ecole Estienne School […]
Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)
A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier […]
Bivalent vaccines derived from measles vaccine
Bivalent vaccines derived from measles vaccine (F. Tangy, N. Escriou) Major childhood diseases, such as polio or measles, have been virtually eliminated since the 60s thanks to the use of live-attenuated vaccines. Today, millions […]
A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection (E14305984.8)
The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in […]
2018DI-tector: defective interfering viral genomes detector for next generation sequencing data, RNA 2018 Jul;.
2018RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes., Cell Rep. 2018 Jul 10;24(2):320-328.
2017Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response, Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17.
2017Identification of a small molecule that primes the type I interferon response to cytosolic DNA, Sci Rep. 2017 May 31;7(1):2561.
2016Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells., Oncoimmunology. 2016 Nov 18;6(1):e1261240.
2016Comparative analysis of viral RNA signatures on different RIG-I-like receptors, Elife 2016 Mar;5.
2015Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
2015Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial, Lancet Infect Dis 2015 May;15(5):519-27.
2015[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening], Med Sci (Paris) 2015 Jan;31(1):98-104.
2015Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH), J. Med. Chem. 2015 Jan;58(2):860-77.
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