Workshop: Bacterial RNAseq
We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation Le but du projet Biologie Intégrative des Maladies Infectieuses Emergentes (IBEID), coordonné par les professeurs Philippe Sansonetti et Pascale Cossart, est de développer une structure pour anticiper et lutter contre les maladies […]
Biology of anaerobic biofilm formed by Clostridium difficile and their role in infections
Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]
The regulatory network of sporulation and spore morphogenesis in Clostridium difficile
Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]
Control of toxin synthesis and secretion in Clostridium difficile
The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]
Pathogenomic analysis of high potential virulent strains of C. difficile
Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]
Biofilms formed by anaerobes
Although many clinically and ecologically relevant processes are known to be performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in aerobic conditions. We use in vitro anaerobic culture systems […]
Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains
The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]
2023The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile., NPJ Biofilms Microbiomes 2023 May; 9(1): 24.
2022c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile., Sci Signal 2022 Sep; 15(750): eabn8171.
2022Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation., Proc Natl Acad Sci U S A 2022 02; 119(7):e2111228119. doi: 10.1073/pnas.2111228119. .
2021In vivo commensal control of Clostridioides difficile virulence., Cell Host Microbe 2021 Nov; 29(11): 1693-1708.e7.
2021Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile., ISME J 2021 Jun; (): .
2021Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile., mBio 2021 May; 12(3): .
2021Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones., J Am Chem Soc 2021 03; 143(10): 3697-3702.
2021Identification of RNAs bound by Hfq reveals widespread RNA partners and a sporulation regulator in the human pathogen Clostridioides difficile., RNA Biol 2021 Feb; (): 1-22.
2020Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile., Commun Biol 2020 Nov; 3(1): 718.
2020How the Anaerobic Enteropathogen Clostridioides difficile Tolerates Low O2 Tensions., mBio 2020 Sep; 11(5): .
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