Workshop: Bacterial RNAseq
We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation Le but du projet Biologie Intégrative des Maladies Infectieuses Emergentes (IBEID), coordonné par les professeurs Philippe Sansonetti et Pascale Cossart, est de développer une structure pour anticiper et lutter contre les maladies […]
Biology of anaerobic biofilm formed by Clostridium difficile and their role in infections
Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]
The regulatory network of sporulation and spore morphogenesis in Clostridium difficile
Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]
Control of toxin synthesis and secretion in Clostridium difficile
The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]
Pathogenomic analysis of high potential virulent strains of C. difficile
Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]
Biofilms formed by anaerobes
Although many clinically and ecologically relevant processes are known to be performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in aerobic conditions. We use in vitro anaerobic culture systems […]
Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains
The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]
2020Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile., Commun Biol 2020 Nov; 3(1): 718.
2020How the Anaerobic Enteropathogen Clostridioides difficile Tolerates Low O2 Tensions., mBio 2020 Sep; 11(5): .
2020Clostridioides difficile para-Cresol Production Is Induced by the Precursor para-Hydroxyphenylacetate., J Bacteriol 2020 Aug; 202(18): .
2020Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile., Front Microbiol 2020 ; 11(): 1939.
2019The Ser/Thr Kinase PrkC Participates in Cell Wall Homeostasis and Antimicrobial Resistance in Clostridium difficile., Infect Immun 2019 08; 87(8): .
2019A microbiota-generated bile salt induces biofilm formation in, NPJ Biofilms Microbiomes 2019;5:14.
2019The σ signalling activation pathway in the enteropathogen Clostridioides difficile, Environ. Microbiol. 2019 Apr;.
2019Role of the global regulator Rex in control of NAD -regeneration in Clostridioides (Clostridium) difficile, Mol. Microbiol. 2019 Mar;.
2019CotL, a new morphogenetic spore coat protein of Clostridium difficile., Environ Microbiol 2019 03; 21(3): 984-1003.
2018Clostridium difficile biofilm: remodeling metabolism and cell surface to build a sparse and heterogeneously aggregated architecture, Front Microbiol. 2018 Sep 12;9:2084. doi: 10.3389/fmicb.2018.02084. eCollection 2018..
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