Timeline
Julia Chamot-Rooke
Head of Structure
18 Mar 2024
publication
Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms
Read more13 Feb 2024
publication
Do Not Waste Time─Ensure Success in Your Cross-Linking Mass Spectrometry Experiments before You Begin.
Read more26 May 2023
publication
Comparing Top-Down Proteoform Identification: Deconvolution, PrSM Overlap, and PTM Detection.
Read more01 May 2023
publication
Biological differences between FIM2 and FIM3 fimbriae of Bordetella pertussis: not just the serotype
Read more18 Nov 2021
publication
TDFragMapper: a visualization tool for evaluating experimental parameters in top-down proteomics.
Read more08 Nov 2021
29 Sep 2021
03 Aug 2021
publication
De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma.
Read more22 Feb 2021
publication
Advanced In Vivo Cross-Linking Mass Spectrometry Platform to Characterize Proteome-Wide Protein Interactions.
Read more23 Dec 2020
publication
Mass-spectrometry analysis of the human pineal proteome during night and day and in autism.
Read more10 Nov 2020
10 Nov 2020
09 Nov 2020
publication
ProteoCombiner: integrating bottom-up with top-down proteomics data for improved proteoform assessment.
Read more03 Nov 2020
publication
Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry.
Read more05 Oct 2020
01 Oct 2020
publication
Optimization of a Top-Down Proteomics Platform for Closely Related Pathogenic Bacterial Discrimination.
Read more02 Sep 2020
publication
Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry.
Read more02 Jun 2020
publication
Extensive flavivirus E trimer breathing accompanies stem zippering of the post-fusion hairpin.
Read more02 Jun 2020
publication
Structural basis for loading and inhibition of a bacterial T6SS phospholipase effector by the VgrG spike.
Read more05 Feb 2020
publication
Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.
Read more21 Jan 2020
project
TopSpec : Next generation precision antibody profiling – from science fiction to reality
Read more01 Oct 2019
27 Jun 2019
publication
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry
Read more04 Feb 2019
publication
Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra.
Read more25 Oct 2018
18 Oct 2018
publication
Consensus designs and thermal stability determinants of a human glutamate transporter
Read more15 Oct 2018
10 Oct 2018
14 Aug 2018
06 Aug 2018
publication
Characterization of LE3 and LE4, the only lytic phages known to infect the spirochete Leptospira.
Read more14 Feb 2018
02 Feb 2018
publication
Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus
Read more01 Feb 2018
publication
Characterization of homodimer interfaces with cross-linking mass spectrometry and isotopically labeled proteins
Read more12 Jan 2018
publication
Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
Read more21 May 2017
publication
Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.
Read more10 Feb 2017
10 Feb 2017
publication
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis
Read more06 Jan 2017
publication
Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.
Read more23 Aug 2016
publication
Abundant Lysine Methylation and N-Terminal Acetylation in Sulfolobus islandicus Revealed by Bottom-Up and Top-Down Proteomics
Read more13 Jul 2016
publication
MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.
Read more05 Jul 2016
publication
Pseudopilin residue E5 is essential for recruitment by the type 2 secretion system assembly platform.
Read more23 Feb 2016
publication
Bio-guided identification of proteins for the diagnosis of cysticercosis in swine
Read more22 Dec 2015
publication
R vs. S fluoroproline ring substitution: trans/cis effects on the formation of b2 ions in gas-phase peptide fragmentation
Read more07 Dec 2015
publication
Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization
Read more01 Nov 2015
29 Oct 2015
publication
Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy.
Read more16 Sep 2015
publication
Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.
Read more14 Sep 2015
publication
Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation
Read more08 Jul 2015
03 Jul 2015
11 May 2015
15 Apr 2015
publication
Conserved Streptococcus pneumoniae spirosomes suggest a single type of transformation pilus in competence
Read more12 Jan 2015
publication
A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis
Read more01 Oct 2014
publication
Robust and low cost uniform (15)N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications.
Read more15 Jun 2014
publication
Ion source parameters and hydrogen scrambling in the ECD of selectively deuterated peptides
Read more05 May 2014
publication
O-Glycosylation of the N-terminal region of the serine-rich adhesin Srr1 of Streptococcus agalactiae explored by mass spectrometry
Read more01 May 2014
publication
IR action spectroscopy shows competitive oxazolone and diketopiperazine formation in peptides depends on peptide length and identity of terminal residue in the departing fragment
Read more16 Apr 2014
publication
Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics
Read more12 Mar 2014
publication
Complete posttranslational modification mapping of pathogenic Neisseria meningitidis pilins requires top-down mass spectrometry
Read more01 Nov 2013
publication
A combined mass spectrometry strategy for complete posttranslational modification mapping of Neisseria meningitidis major pilin
Read more27 Jun 2013
publication
A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae
Read more14 Apr 2013
publication
Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus
Read more01 Mar 2013
06 Feb 2013
publication
Influence of N-terminal residue composition on the structure of proline-containing b2+ ions
Read more24 Apr 2012
publication
Structural influences on preferential oxazolone versus diketopiperazine b(2+) ion formation for histidine analogue-containing peptides
Read more06 Mar 2012
publication
Assigning structures to gas-phase peptide cations and cation-radicals. An infrared multiphoton dissociation, ion mobility, electron transfer, and computational study of a histidine peptide ion
Read more04 Jun 2011
publication
Dissociation channel dependence on peptide size observed in electron capture dissociation of tryptic peptides
Read more11 Feb 2011
publication
Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination
Read more01 Nov 2010
publication
Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors
Read more11 Aug 2010
publication
The histidine effect. Electron transfer and capture cause different dissociations and rearrangements of histidine peptide cation-radicals
Read more01 Aug 2010
02 Apr 2010
publication
Separation and identification of structural isomers by quadrupole collision-induced dissociation-hydrogen/deuterium exchange-infrared multiphoton dissociation (QCID-HDX-IRMPD)
Read more01 Dec 2009
31 Dec 2008
21 Oct 2008
publication
Structure of electron-capture dissociation fragments from charge-tagged peptides probed by tunable infrared multiple photon dissociation
Read more01 Nov 2007
18 Sep 2007
publication
Electron capture in charge-tagged peptides. Evidence for the role of excited electronic states
Read more05 Sep 2007
publication
Alternative Neisseria spp. type IV pilin glycosylation with a glyceramido acetamido trideoxyhexose residue
Read more25 Apr 2007
publication
The combination of electron capture dissociation and fixed charge derivatization increases sequence coverage for O-glycosylated and O-phosphorylated peptides
Read more30 Mar 2006
01 Mar 2006
publication
Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS
Read more15 Oct 2005
publication
Characterization of toxins within crude venoms by combined use of Fourier transform mass spectrometry and cloning
Read more01 Nov 1975
publication