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© Research
Publication : Structure (London, England : 1993)

Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Structure (London, England : 1993) - 03 Nov 2020

Leitner A, Bonvin AMJJ, Borchers CH, Chalkley RJ, Chamot-Rooke J, Combe CW, Cox J, Dong MQ, Fischer L, Götze M, Gozzo FC, Heck AJR, Hoopmann MR, Huang L, Ishihama Y, Jones AR, Kalisman N, Kohlbacher O, Mechtler K, Moritz RL, Netz E, Novak P, Petrotchenko E, Sali A, Scheltema RA, Schmidt C, Schriemer D, Sinz A, Sobott F, Stengel F, Thalassinos K, Urlaub H, Viner R, Vizcaíno JA, Wilkins MR, Rappsilber J,

Link to Pubmed [PMID] – 33065067

Link to DOI [DOI] – S0969-2126(20)30336-110.1016/j.str.2020.09.011

Structure 2020 Nov; 28(11): 1259-1268

Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.

https://pubmed.ncbi.nlm.nih.gov/33065067