HDX (Hydrogen Deuterium Exchange) MS is a powerful tool to monitor conformational changes in proteins and to characterize protein-protein interactions. The Synapt G2-Si HDMS mass spectrometer used for HDX experiments is also equipped with an HDX Manager (maintaining valves and columns at low temperature) and a LEAP-PAL robot for automated sample handling at high-throughput. Our lab has gained a strong expertise in the analysis of integral membrane proteins. As part of a collaboration with the group of Nicolas Reyes (Institut Pasteur, Paris), we are currently studying the conformation and dynamics of several integral membrane protein transporters considered as potential drug targets. HDX-MS can also be used for epitope mapping. For more information, contact firstname.lastname@example.org (responsible for the Synapt instrument and HDX-MS experiments).