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© Research
Publication : Journal of fungi (Basel, Switzerland)

Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of fungi (Basel, Switzerland) - 02 Feb 2018

Li J, Mouyna I, Henry C, Moyrand F, Malosse C, Chamot-Rooke J, Janbon G, Latgé JP, Fontaine T

Link to Pubmed [PMID] – 29393895

J Fungi (Basel) 2018 Feb;4(1)

Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall polymers. GPIs follow a specific biosynthetic pathway in the endoplasmic reticulum. After the transfer of the protein onto the GPI-anchor, a lipid remodeling occurs to substitute the diacylglycerol moiety by a ceramide. In addition to GPI-APs, produces a GPI-anchored polysaccharide, the galactomannan (GM), that remains unique in the fungal kingdom. To investigate the role of the GPI pathway in the biosynthesis of the GM and cell wall organization, the deletion of -coding for a phospholipase required for the first step of the GPI lipid remodeling-was undertaken. Biochemical characterization of the GPI-anchor isolated from GPI-APs showed that the deficient mutant produced a lipid anchor with a diacylglycerol. The absence of a ceramide on GPI-anchors in the mutant led to a mislocation of GPI-APs and to an alteration of the composition of the cell wall alkali-insoluble fraction. On the other hand, the GM isolated from the mutant membranes possesses a ceramide moiety as the parental strain, showing that GPI anchor of the GM follow a distinct unknown biosynthetic pathway.

https://www.ncbi.nlm.nih.gov/pubmed/29393895