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© Research
Publication : Journal of the American Chemical Society

Structure of electron-capture dissociation fragments from charge-tagged peptides probed by tunable infrared multiple photon dissociation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of the American Chemical Society - 21 Oct 2008

Frison G, van der Rest G, Turecek F, Besson T, Lemaire J, Maître P, Chamot-Rooke J

Link to Pubmed [PMID] – 18937474

J. Am. Chem. Soc. 2008 Nov;130(45):14916-7

In this study, we propose the first spectroscopic structural characterization of c-type ions produced by ECD of a peptide. The structure of c-type ions formed by electron capture dissociation and the overall mechanism leading to their formation are still a question of debate. Depending on the mechanism, c-type ions have been proposed to have either an enol-imine structure (-C(OH)NH) or an amide one (-C(O)-NH2). Since these ions are isomeric, mass spectrometry only cannot discriminate between them, but infrared spectroscopy can bring experimental evidence and help determine which scheme is operative. Using the coupling between a tunable free electron laser and a FT-ICR mass spectrometer, we show that c-type ions have an amide structure, characterized by an IR signature of the C=O stretch at 1731 cm(-1). This result is particularly interesting from the perspective of the elucidation of the ECD mechanism.

http://www.ncbi.nlm.nih.gov/pubmed/18937474