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  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
05
Jan 2016
Status
Ongoing
Members
6
Structures
1

About

Covalent cross-linking combined to mass spectrometry is a powerful approach to address both the structure and composition of protein complexes. To improve the crucial stage of detection and characterization of cross-linked peptides, we have developed a new generation of cross-linking agents based on click-chemistry. The synthesis of these reagent is performed by the group of Prof. Pierre-Yves Renard (University of Rouen).

A new pipeline called e-XL-MS for enhanced-Cross-Linking Mass Spectrometry has been developed recently by our group and published in Analytical Chemistry.

This pipeline is currently extended to in vivo analysis for the analysis of endogenous bacterial protein complexes.

Fundings