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© Research
Publication : Journal of pineal research

Mass-spectrometry analysis of the human pineal proteome during night and day and in autism.

Team: Mass Spectrometry for Biology
Team: Human Genetics and Cognitive Functions
Member: Mariette Matondo
Member: Julia Chamot-Rooke
Member: Thomas Bourgeron
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of pineal research - 23 Dec 2020

Dumas G, Goubran-Botros H, Matondo M, Pagan C, Boulègue C, Chaze T, Chamot-Rooke J, Maronde E, Bourgeron T,

Link to Pubmed [PMID] – 33368564

Link to DOI – 10.1111/jpi.12713

J Pineal Res 2020 Dec; (): e12713

The human pineal gland regulates day-night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass spectrometry-based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day, and, compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane-bounded vesicle-related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.