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© Research
Publication : The American journal of gastroenterology

Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The American journal of gastroenterology - 01 Nov 1975

Korelitz BI, Sommers SC

Link to Pubmed [PMID] – 2008

Am. J. Gastroenterol. 1975 Nov;64(5):365-70

To evaluate responses to medical therapy in ulcerative colitis, rectal biopsies of patients with active untreated disease, individuals with positive and negative sigmoidoscopic findings treated with salicylazosulfapyridine, prednisone and 6-mercaptopurine, alone and in combinations and noncolitis controls were compared histologically. Predominant histological observations were analyzed statistically. There were fewer crypt abscesses but more mucosal edema after all forms of therapy. Quantitative histopathological analysis failed to demonstrate that the response to one drug was significantly different from another.

http://www.ncbi.nlm.nih.gov/pubmed/2008