Link to Pubmed [PMID] – 30715205
Bioinformatics 2019 Feb;
We present the first tool for unbiased quality control of top-down proteomics datasets.
Motivation: Our tool can select high-quality top-down proteomics spectra, serve as a gateway for building top-down spectral libraries and, ultimately, improve identification rates.
Results: We demonstrate that a twofold rate increase for two E. coli top-down proteomics datasets may be achievable.
Availability: http://patternlabforproteomics.org/tdgc, freely available for academic use.https://www.ncbi.nlm.nih.gov/pubmed/30715205