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  • Director of Center
  • Director of Department
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© Jean-Claude Antoine
Leishmania mexicana amazonensis
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

project
Ongoing
5 Members

“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”

Gérald Spaeth (PI)

Recipient: Gerald Spaeth, coordinator Agency: Campus France, MEAE, Type: Bi-national program France/Israel, 04/2018 – 03/2020  Leishmaniasis is among the five most serious parasitic diseases worldwide. The cutaneous form of the disease is prevalent in […]
project
Ongoing
4 Members

ANR Patho-Methylome – The role of lysine methylation in host-pathogen interactions

Jonathan Weitzman (PI)

The interaction between two eukaryotic genomes provides a fascinating example of co-evolution of host-parasite interactions. Two genomes, two epigenomes, two cellular systems living together. Our proposal focuses on the fascinating features of the interaction […]
project
Ongoing
3 Members

International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.

Gérald Spaeth (PI)

Recipient: Gerald Spaeth, PI Agency: Pasteur Institute, Type: Collaborative grant, 01/2016 – 12/2019 Based on ongoing collaborative actions we propose the creation of an IMU between three teams at IP Paris (G. Spaeth), IP […]
project
Completed
5 Members

PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery

Joo Hwan No (PI)

Our PTR project investigates at the complex interface between the intracellular pathogen Leishmania and its macrophage host cell. We will apply systems-wide analyses to elucidate the molecular mechanisms underlying the reciprocal metabolic relationship between […]
project
Completed
7 Members

PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection

Eric Prina (PI)

Our proposal aims to decipher novel subversion strategies used by Leishmania (i) to withstand, circumvent or inhibit anti-microbial activities of host macrophages and (ii) to interfere with the induction of Leishmania-specific immune responses. We […]
project
Completed
4 Members

FP7 Anti-Parasitic Drug Discovery in Epigenetics (A-ParaDDisE)

Raymond J. Pierce (PI)

We will employ a target-based strategy for the development of novel drug leads against epigenetic targets in schistosomiasis, leishmaniasis, Chagas disease and malariafocusing on key histone modifying enzymes (HME), in particular those involved in […]
project
Completed
9 Members

ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening

Najma Rachidi (PI)

The protozoan parasite Leishmania donovani causes fatal visceral leishmaniasis, one of the most neglected tropical diseases. In the absence of economic incentive, serious Research and Development (R&D) investments into anti-leishmanial drug development lack from […]
project
Completed
14 Members

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

Gérald Spaeth (PI)

Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect […]

Publications

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