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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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© Jean-Claude Antoine
Leishmania mexicana amazonensis
Scientific Fields
Diseases
Organisms
Applications
Technique

About

In mammals, Leishmania develop as strictly intracellular amastigotes within acidic parasitophorous vacuoles of host macrophages. These important innate immune cells are at the crossroads of various host responses including sensing of infections, induction of appropriate anti-microbial adaptive immune responses, or wound-healing processes. Leishmania has evolved strategies to hijack these essential cellular functions for their own benefit causing the immuno-pathologies associated with the different forms of leishmaniasis. At the core of these pathologies lies the parasite’s capacity to inhibit macrophage pro-inflammatory responses and to exploit host cell metabolic resources, such as fatty acid biosynthesis or arginine catabolism. Sheng ZHANG’s project will focus on identifying key factors of processes of Leishmania/macrophage interaction with aim to discover novel anti-leishmanial strategies. Before working at Institut Pasteur, Sheng ZHANG studied on inactivated poliovirus vaccine at Wuhan Institute of Biological Products Co., Ltd.