Synthetic carbohydrate-based conjugates as Shigella vaccine components: design, synthesis, selection and process validation
A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Sitting at the frontier between the fields of Chemistry, Glycosciences, and Vaccinology, FlexBiVac is a multidisciplinary project aimed at demonstrating the proof of concept for a new generation of polysaccharide-based multivalent vaccines. The concept […]
At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]
Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools
Synthetic peptides and conjugates thereof as potential antivirals (col. H. Lortat-Jacob (CEA, Grenoble), D. Bonnaffé (ICMMO, Orsay) A bi-substrate synthetic glycopeptide resulting from the covalent linkage between a CD4 peptide mimetic and a heparan […]
Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components
Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]
Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides
2018Bacteriophage Sf6 Tailspike Protein for Detection of Pathogens, Viruses 2018 Aug;10(8).
2017Dirhamnolipids secreted from Pseudomonas aeruginosa modify anjpegungal susceptibility of Aspergillus fumigatus by inhibiting β1,3 glucan synthase activity, ISME J 2017 07;11(7):1578-1591.
2016Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a, Chemistry 2016 Jul;22(31):10892-911.
2016Efficient iterative synthesis of O-acetylated tri- to pentadecasaccharides related to the lipopolysaccharide of Shigella flexneri type 3a via di- and trisaccharide glycosyl donors, Chem Asian J 2016 Jul;.
2016A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity, Bioconjug. Chem. 2016 Mar;.
2015Investigation on the synthesis of Shigella flexneri-specific oligosaccharides using disaccharides as potential transglucosylase acceptor substrates, J. Org. Chem. 2015 Sep;.
2015Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate, Chem. Commun. (Camb.) 2015 Feb;51(13):2581-4.
2015Computer-aided design of sequence libraries for the engineering of transglucosylase binding subsites to enable glucosylation of an unnatural disaccharide motif of relevance for bacterial antigen synthesis, ACS Catalysis 2015, 5, 1186-98.
2014Synthesis of the zwitterionic repeating unit of the O-antigen from Shigella sonnei and chain elongation at both ends, Org. Lett. 2014 Sep;16(18):4892-5.
2014Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation, Org. Biomol. Chem. 2014 Oct;12(39):7728-49.
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