Synthetic carbohydrate-based conjugates as Shigella vaccine components: design, synthesis, selection and process validation
A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Sitting at the frontier between the fields of Chemistry, Glycosciences, and Vaccinology, FlexBiVac is a multidisciplinary project aimed at demonstrating the proof of concept for a new generation of polysaccharide-based multivalent vaccines. The concept […]
At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]
Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools
Synthetic peptides and conjugates thereof as potential antivirals (col. H. Lortat-Jacob (CEA, Grenoble), D. Bonnaffé (ICMMO, Orsay) A bi-substrate synthetic glycopeptide resulting from the covalent linkage between a CD4 peptide mimetic and a heparan […]
Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components
Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]
Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides
2023Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose, Carbohydr. Res. 2023, 534, 108985.
2022The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella., ACS Cent Sci 2022 Apr; 8(4): 449-460.
2022Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella: State-of-the-Art for a Monovalent Prototype and Challenges., Vaccines (Basel) 2022 Mar; 10(3): .
2022Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans., Anal Chem 2022 02; 94(4): 2279-2287.
2021Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides., Sci Rep 2021 10; 11(1): 20294.
2021Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide, Org. Chem. Front..
2021Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study., Lancet Infect Dis 2021 04; 21(4): 546-558.
2021Exploratory N-Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides., Chemistry 2021 Mar; 27(18): 5694-5711.
2021Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O-Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core., J Org Chem 2021 02; 86(3): 2058-2075.
2021Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens., Sci Rep 2021 01; 11(1): 2474.
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