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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Chemistry (Weinheim an der Bergstrasse, Germany)

Exploratory N-protecting group manipulation for the total synthesis of zwitterionic Shigella sonnei oligosaccharides.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chemistry (Weinheim an der Bergstrasse, Germany) - 13 Dec 2020

Dhara D, Mulard LA,

Link to Pubmed [PMID] – 33314456

Link to DOI – 10.1002/chem.202003480

Chemistry 2020 Dec; ():

Shigella sonnei surface polysaccharides are well-established protective antigens against this major cause of diarrhoeal disease. They also qualify as unique zwitterionic polysaccharides (ZPSs) featuring a disaccharide repeating unit made of two 1,2- trans linked rare aminodeoxy sugars, a 2-acetamido-2-deoxy-l-altruronic acid (l-Alt p NAcA) and a 2-acetamido-4-amino-2,4,6-trideoxy-d-galactopyranose (AAT). Herein, the stereoselective synthesis of S. sonnei oligosaccharides comprising two and three repeating units is reported for the first time. Several sets of up to seven protecting groups were explored, shedding light on the singular conformational behavior of protected altrosamine and altruronic residues. A disaccharide building block equipped with three distinct N -protecting groups and featuring the uronate moiety already in place was designed to accomplish the iterative high yielding glycosylation at the axial 4-OH of the altruronate component and achieve the challenging full deprotection step. Key to the successful strategy was the use of a diacetyl strategy whereby the N -acetamido group of the l-Alt p NAcA is masked in the form of an imide.

https://pubmed.ncbi.nlm.nih.gov/33314456