Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components
Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]
At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]
Sitting at the frontier between the fields of Chemistry, Glycosciences, and Vaccinology, FlexBiVac is a multidisciplinary project aimed at demonstrating the proof of concept for a new generation of polysaccharide-based multivalent vaccines. The concept […]
A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides
2018Bacteriophage Sf6 Tailspike Protein for Detection of Pathogens, Viruses 2018 Aug;10(8).
2017Dirhamnolipids secreted from Pseudomonas aeruginosa modify anjpegungal susceptibility of Aspergillus fumigatus by inhibiting β1,3 glucan synthase activity, ISME J 2017 07;11(7):1578-1591.
2016Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a, Chemistry 2016 Jul;22(31):10892-911.
2016Efficient iterative synthesis of O-acetylated tri- to pentadecasaccharides related to the lipopolysaccharide of Shigella flexneri type 3a via di- and trisaccharide glycosyl donors, Chem Asian J 2016 Jul;.
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