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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Starting Date
04
Nov 2015
Status
Ongoing
Members
6
Structures
4

About

Development of specific imaging nanoprobes against intracerebral targets is a challenging field of research, particularly for the diagnosis of neurodegenerative diseases. Probes based on camelid single-domain antibody-fragments (VHHs or nanobodies) are promising tools due to their high specificity and their ability to cross the blood brain barrier.

The overall objective of the project is to use VHH-derived probes for the direct detection of the main neuropathological hallmarks of Alzheimer’s disease. Our specific aim is to develop chemically-defined VHH conjugates with a contrast agent to allow the in vivo detection of these brain lesions by magnetic resonance imaging. Methods for the efficient conjugation of available probes to appropriate contrast agents are being developed.