Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components
Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]
Synthetic carbohydrate-based conjugates as Shigella vaccine components: design, synthesis, selection and process validation
2015Investigation on the synthesis of Shigella flexneri-specific oligosaccharides using disaccharides as potential transglucosylase acceptor substrates, J. Org. Chem. 2015 Sep;.
2013CGTase-catalysed cis-glucosylation of L-rhamnosides for the preparation of Shigella flexneri 2a and 3a haptens, Chembiochem 2014 Jan;15(2):293-300.
2013Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxydation, Tetrahedron 2013; 69:10337-50.
2013Structural studies of the O-acetyl containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof, Eur. J. Org. Chem. 2013, 4085–106.
2008Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens, Tetrahedron 2008; 64: 10558-72.
2004Total synthesis of a tetra- and two pentasaccharide fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a, Tetrahedron 2004; 60: 2475-88.