Timeline
Bruno Dupuy
Head of Structure
24 Dec 2024
publication
Clostridioides difficile binary toxin CDT induces biofilm-like persisting microcolonies
Read more06 Dec 2024
publication
Comment on: Co-occurrence of the cephalosporinase cepA and carbapenemase cfiA genes in a Bacteroides fragilis Division II strain: an unexpected finding
Read more17 Sep 2024
publication
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota.
Read more10 Jul 2024
01 Jul 2024
project
Étude de l’activité biologique et du mécanisme d’action de copolypeptoïdes cationiques sur Clostridioides difficile “THERAPEPTICS” (2024-039)
Read more19 Jan 2024
01 Jan 2024
publication
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology.
Read more01 Jan 2024
publication
SpoIVA is an essential morphogenetic protein for the formation of heat- and lysozyme-resistant spores in Clostridium sporogenes NBRC 14293.
Read more01 Dec 2023
publication
Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile.
Read more15 Sep 2023
26 Jun 2023
11 May 2023
publication
The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile.
Read more01 May 2023
publication
Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling.
Read more13 Sep 2022
news
Highlighted paper: “c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile”, Oberkampf et al. Science Signalling; Sept 2022; Pathogenesis of Bacterial anaerobes Unit; Microbiology Dpt.
Read more06 Sep 2022
publication
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile.
Read more01 May 2022
publication
Core-, pan- and accessory genome analyses of Clostridium neonatale: insights into genetic diversity.
Read more01 Apr 2022
15 Feb 2022
publication
Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation.
Read more08 Feb 2022
publication
A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridiumsordellii.
Read more20 Dec 2021
news
Highlighted publication: “In vivo commensal control of Clostridioides difficile virulence” Girinathan et al., Cell Host ; Microbes, Pathenogenesis of Bacterial Anaerobes team
Read more10 Nov 2021
10 Nov 2021
publication
Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile.
Read more10 Sep 2021
publication
Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections.
Read more21 Jun 2021
publication
Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile.
Read more18 May 2021
publication
Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile.
Read more17 Mar 2021
publication
Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones.
Read more25 Feb 2021
publication
Identification of RNAs bound by Hfq reveals widespread RNA partners and a sporulation regulator in the human pathogen Clostridioides difficile.
Read more27 Nov 2020
publication
Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile.
Read more08 Sep 2020
publication
How the Anaerobic Enteropathogen Clostridioides difficile Tolerates Low O2 Tensions.
Read more25 Aug 2020
publication
Clostridioides difficile para-Cresol Production Is Induced by the Precursor para-Hydroxyphenylacetate.
Read more01 Jan 2020
publication
Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile.
Read more11 Dec 2019
publication
An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
Read more23 Jul 2019
publication
The Ser/Thr Kinase PrkC Participates in Cell Wall Homeostasis and Antimicrobial Resistance in Clostridium difficile.
Read more09 May 2019
29 Apr 2019
publication
The σ signalling activation pathway in the enteropathogen Clostridioides difficile
Read more18 Mar 2019
publication
Role of the global regulator Rex in control of NAD -regeneration in Clostridioides (Clostridium) difficile
Read more25 Feb 2019
21 Feb 2019
20 Aug 2018
publication
Clostridium difficile biofilm: remodeling metabolism and cell surface to build a sparse and heterogeneously aggregated architecture
Read more29 Jul 2018
publication
A microfluidic fluidized bed to capture, amplify and detect bacteria from raw samples
Read more12 Jun 2018
publication
Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in
Read more28 Mar 2018
publication
Micro-nano-bio acoustic system for the detection of foodborne pathogens in real samples
Read more12 Mar 2018
26 Feb 2018
publication
Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile
Read more17 Nov 2017
publication
High prevalence and genetic diversity of large phiCD211/phiCDIF1296T-like prophages in Clostridioides difficile
Read more04 Sep 2017
publication
Advanced immunocapture of milk-borne Salmonella by microfluidic magnetically stabilized fluidized bed
Read more21 Mar 2017
publication
The alternative sigma factor σ plays a crucial role in adaptive strategies of Clostridium difficile during gut infection
Read more15 Feb 2017
publication
Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291
Read more10 Oct 2016
publication
A new microfluidic approach for the one-step capture, amplification and label-free quantification of bacteria from raw samples
Read more23 Sep 2016
project
Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains
Read more22 Sep 2016
21 Sep 2016
publication
What’s a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives
Read more15 Sep 2016
publication
A Recombination Directionality Factor Controls the Cell Type-Specific Activation of σK and the Fidelity of Spore Development in Clostridium difficile
Read more31 Aug 2016
publication
Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes.
Read more21 Jul 2016
publication
Control of Clostridium difficile Physiopathology in Response to Cysteine Availability
Read more28 Jun 2016
publication
Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis
Read more14 May 2016
26 Mar 2016
publication
Cpe1786/IscR of Clostridium perfringens represses expression of genes involved in Fe-S cluster biogenesis
Read more01 Jan 2016
publication
Micro-Nano-Bio Diagnostic System for Food Pathogen Detection Revolutionizes Food Safety Management & Protects Consumers Health
Read more11 Nov 2015
publication
Plasma nanotextured polymeric lab-on-a-chip for highly efficient bacteria capture and lysis
Read more09 Nov 2015
14 Oct 2015
project
Biology of anaerobic biofilm formed by Clostridium difficile and their role in infections
Read more13 Oct 2015
project
The regulatory network of sporulation and spore morphogenesis in Clostridium difficile
Read more01 Sep 2015
17 Aug 2015
11 May 2015
10 Jan 2015
publication
Repressor activity of the RpoS/σS-dependent RNA polymerase requires DNA binding
Read more01 Dec 2014
publication
Inter- and intraspecies transfer of a Clostridium difficile conjugative transposon conferring resistance to MLSB
Read more15 Oct 2014
15 Sep 2014
30 Jun 2014
publication
Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile
Read more09 Jun 2014
publication
Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole
Read more19 May 2014
publication
The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection
Read more08 May 2014
publication
Expanding the RpoS/σS-network by RNA sequencing and identification of σS-controlled small RNAs in Salmonella
Read more08 Apr 2014
10 Feb 2014
publication
COV2HTML: a visualization and analysis tool of bacterial next generation sequencing (NGS) data for postgenomics life scientists
Read more23 Jan 2014
publication
Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation
Read more16 Dec 2013
publication
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR
Read more03 Oct 2013
publication
Genome-wide analysis of cell type-specific gene transcription during spore formation in Clostridium difficile
Read more16 Sep 2013
09 May 2013
publication
Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile
Read more18 Sep 2012
publication
Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Read more07 Jun 2012
publication
Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE
Read more13 Oct 2011
publication
The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile
Read more13 Apr 2011
28 Dec 2010
07 Sep 2010
publication
Global regulation of gene expression in response to cysteine availability in Clostridium perfringens
Read more26 Feb 2010
publication
Characterization of Acp, a peptidoglycan hydrolase of Clostridium perfringens with N-acetylglucosaminidase activity that is implicated in cell separation and stress-induced autolysis
Read more01 Jan 2010
publication
Molecular methods to study transcriptional regulation of Clostridium difficile toxin genes
Read more05 Oct 2009
publication
Effects of subinhibitory concentrations of antibiotics on colonization factor expression by moxifloxacin-susceptible and moxifloxacin-resistant Clostridium difficile strains
Read more23 Sep 2009
17 Aug 2009
01 Jun 2008
01 Jun 2007
publication
Clostridium difficile toxin expression is inhibited by the novel regulator TcdC
Read more25 Jun 2006
publication
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Read more01 May 2006
publication
Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors
Read more01 Jan 2006
publication
Isolation of RNA polymerase from Clostridium difficile and characterization of glutamate dehydrogenase and rRNA gene promoters in vitro and in vivo
Read more29 Dec 2005
publication
Regulation of toxin and bacteriocin synthesis in Clostridium species by a new subgroup of RNA polymerase sigma-factors
Read more01 Feb 2005
01 Feb 2005
publication
Transcription activation of a UV-inducible Clostridium perfringens bacteriocin gene by a novel sigma factor
Read more01 Jan 2005
publication
BotR/A and TetR are alternative RNA polymerase sigma factors controlling the expression of the neurotoxin and associated protein genes in Clostridium botulinum type A and Clostridium tetani
Read more01 Jun 2004
publication
The spatial organization of the VirR boxes is critical for VirR-mediated expression of the perfringolysin O gene, pfoA, from Clostridium perfringens
Read more01 Apr 2004
publication
Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani
Read more01 Apr 2003
publication
Expression of Clostridium difficile toxins A and B and their sigma factor TcdD is controlled by temperature
Read more01 Nov 2002
publication
Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression
Read more24 Apr 2001
publication
Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor
Read more01 Jan 1998
01 Jun 1997
26 Jul 1996
publication
Genome mapping of Clostridium perfringens strains with I-CeuI shows many virulence genes to be plasmid-borne
Read more01 Oct 1995
publication
Rapid expansion of the physical and genetic map of the chromosome of Clostridium perfringens CPN50
Read more01 Mar 1994
publication
Type IV prepilin peptidase gene of Neisseria gonorrhoeae MS11: presence of a related gene in other piliated and nonpiliated Neisseria strains
Read more01 Sep 1992
publication
Role of pilA, an essential regulatory gene of Neisseria gonorrhoeae, in the stress response
Read more01 Jul 1992
publication
PulO, a component of the pullulanase secretion pathway of Klebsiella oxytoca, correctly and efficiently processes gonococcal type IV prepilin in Escherichia coli
Read more01 Mar 1992
publication
An enzyme with type IV prepilin peptidase activity is required to process components of the general extracellular protein secretion pathway of Klebsiella oxytoca
Read more01 Dec 1991
01 Jan 1991
publication