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© Michel-Robert Popoff
Clostridium difficile en microscopie à contraste de phase. On distingue des bactéries sporulées, non sporulées et d'autres en cours de lyse (destruction). Bactérie de l'environnement (sol, eau, foin, sable), elle est à l'origine d'infections nosocomiales survenant après un traitement antibiotique : Clostridium difficile prédomine alors que les autres bactéries de la flore intestinale ont été détruites. L'infection peut provoquer deux types de pathologies graves : les colites pseudo-membraneuses dont l'origine est quasiment due à 100 % à C. difficile et la diarrhée post-antibiothérapie due à C. difficile dans 30 % des cas de ces diarrhées.
Scientific Fields
Diseases
Organisms
Applications
Technique

Courses

09:00
06
Jun 2016
Course

Workshop: Bacterial RNAseq

We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
Pathogenesis of Bacterial Anaerobes
Biomics
Microbiology
Marc Monot
Isabelle Martin-Verstraete
Olga Soutourina
Bruno Dupuy
Odile Sismeiro
Rachel Legendre
Fabien Mareuil
Olivia Doppelt-Azeroual
2016-06-06 09:00:00 2016-06-10 17:00:00 Europe/Paris Workshop: Bacterial RNAseq We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […] 28 Rue du Docteur Roux, Paris, France

Projects

project
Ongoing
5 Members

Biology of anaerobic biofilm formed by C. difficile and their role in the CD infections

Bruno Dupuy (PI)

Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]
project
Completed
3 Members

The regulatory network controlling spore formation in Clostridium difficile

Isabelle Martin-Verstraete (PI)

Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]
project
Ongoing
5 Members

Global regulation of C. difficile toxin production

Bruno Dupuy (PI)

We elucidated the role of the carbon catabolite repression system (CCR) in the control of CD toxin synthesis and demonstrated that CcpA, the global regulator of the CCR, is a key factor controlling in […]

Publications

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