Lucie Peduto obtained her PhD in Tumor Biology at the University of Lausanne/CHUV (Switzerland) and Ecole Pratique des Hautes Etudes in Paris. She joined the lab of Carl Blobel at Sloan-Kettering Institute (New York) for a postdoctoral training on the role of ADAMs proteins in cancer, and became faculty member of the Department of Immunology at Institut Pasteur (Paris) in 2010, where she is directing since 2016 a Research Unit focusing on the role of the stromal microenvironment in cancer and fibrosis. Lucie Peduto is currently Associate Professor (Directeur de Recherche) at Institut Pasteur, and holds an accreditation as research director from the University Paris Descartes. She has received support from La Ligue contre le Cancer, l’ARC, l’ANR, FRM and was awarded an ERC Consolidator Grant (European Research Council) for her work on cancer and fibrosis.
CoNCEPT – Clinical NeurosCiencE & PsychiaTry
CoNCEPT is an international research collaboration between the PM Lledo and G Eberl’s Labs (Institut Pasteur, Paris), and the McMaster University and St Joseph’s Hospital (Canada). This international collaboration, endorsed by the French Embassy in […]
Oncobiomics – THE (heterogenity tumor ecosystem)
The Oncobiomics project is conducted in the HTE (heterogenity tumor ecosystem) national program launched by the cancer nation institute (Inca) in the third national cancer plan 2014-2019. It’s a consortium project involving 8 teams […]
Role of nutrition and the microenvironment in cancer development
Cancer is increasingly recognized as a multifactorial disease, resulting from a dysregulated communication between different cell types of the tumor microenvironment, including cancer cells, infiltrating immune cells and resident stromal cells, altogether modulated by […]
ERC-CoG-PERIF Perivascular cells at the crossroads of inflammation, regeneration and fibrosis
The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
The stromal microenvironment in intestinal homeostasis / immunity
The intestine contains abundant and heterogeneous populations of stromal cells. Using several genetic approaches as well as intestinal organoid models, we are investigating the role of the stromal microenvironment in intestinal homeostasis and repair, and […]
The tumor stromal microenvironment
Tumor progression, invasion and ultimately metastasis result from interactions between cancer cells and their supporting stromal microenvironment. The tumor stromal microenvironment share many similarities with fibrotic stroma and comprises extracellular matrix components, as well […]
2022PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms., Cell Stem Cell 2022 May; 29(5): 856-868.e5.
2021T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way., iScience 2021 Mar; 24(3): 102158.
2020Mesenchymal perivascular cells in immunity and disease, Curr. Opin. Immunol. 2020 May;64:50-55.
2019Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors, Nucleic Acids Res. 2019 Feb;.
2018Peyer’s patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion., J Exp Med 2018 11; 215(11): 2936-2954.
2018Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation, Immunity 2018 Jan;48(1):120-132.e8.
2018Intestinal Stem Cells and Their Niche at Homeostasis and Under Stress, https://doi.org/10.1016/bs.asn.2017.12.002.
2018The perivascular origin of pathological fibroblasts, J. Clin. Invest. 2018 01;128(1):54-63.
2017CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury, Proc. Natl. Acad. Sci. U.S.A. 2017 01;114(4):E506-E513.
2016B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer, Int. J. Cancer 2016 Sep;139(6):1358-71.
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