Marc Monot

Artemisinins, combined with another antimalarial, are the core component of Artemisinin-based Combination Therapies (ACTs): the front-line antimalarial drugs. Today the fight against malaria faces to the emergence of resistance of the parasite Plasmodium falciparum […]

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Clostridium difficile (CD), recently reclassified as Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease in hospitals worldwide. The incidence and severity of CD infections […]

Supervision of the quality management system (QMS) based on International Standards of Organization ISO9001 requirements is one of Biomics’ missions. The platform has been certified since 2017. An external audit system allows us to […]

The Oncobiomics project is conducted in the HTE (heterogenity tumor ecosystem) national program launched by the cancer nation institute (Inca) in the third national cancer plan 2014-2019. It’s a consortium project involving 8 teams […]

NovaSeq 6000 High throughput NGS sequencing is now available at Biomics core facility. This is using the same types of libraries as other Illumina sequencers. Sequencing (only PE150, ≥ 400M reads) is outsourced to […]

PHINDaccess is a twinning initiative aimed to serve as a lever for Omics research performance of the Institut Pasteur de Tunis (IPT), aspiring to raise its positioning as an excellence center in the field […]

Analyses of RNA-Seq data from two related virulent bacteriophages, PAK_P3 and PAK_P4 infecting the bacterium Pseudomonas aeruginosa.

The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]

In bacteria, it is increasingly recognized that ncRNAs play a critical role in adaptive responses and in various metabolic, physiological and pathogenic processes. In Clostridium difficile, by combining in silico analysis, RNAseq and genome-wide […]

Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]

Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]

Necrotizing enterocolitis (NEC) is the most common and serious gastrointestinal disorder among preterm neonates. We aimed to assess specific gut microbes associated with NEC. In 2002, an outbreak of NEC occurred in six neonates within […]

We have used directional RNA-sequencing and complementary assays to explore the SigmaS-dependent transcriptome of Salmonella enterica serovar Typhimurium. This study confirms the large regulatory scope of SigmaS and provides insights into its physiological functions […]

The Human Methylation 450K BeadChip enables the simultaneous quantitative monitoring of more than 480,000 CpG positions. This BeadChip has a 12-sample per array format and requiring only 500 ng of input. A positive methylated […]

Biomics can support genetic linkage analysis, genome-wide association study (GWAS), and Copy Number Variation (CNV) analysis.

For the study of known human variants, Illumina offers a panel of BeadArrays, whose content differs from the number of markers, a few hundreds of thousands of genetic markers to 5,000,000 markers. The platform […]

The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]

Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]

Bacteriophages are the most abundant viruses on earth and display an impressive genetic as well as morphologic diversity. Among those, the most common order of phages is the Caudovirales, whose viral particles packages linear […]

COV2HTML is an interactive web interface, which is addressed to biologists, and allows performing both coverage visualization and analysis of NGS alignments performed on prokaryotic organisms (bacteria and phages). It combines two processes: a […]

The single cell transcriptomics, epigenetic and genomics are supported by collaborative effort of the CB UTechS and Biomics. The CB UTechS gathers expertise and high-end instrumentation for single cell phenotyping and sorting, single cell […]