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🧫 When training sparks inspiration! Spotlight on the Advanced Immunology Pasteur Course This course immerses participants in the immune system's complexities through lectures seminars, and cutting-edge lab work. 🎥In this video Amélie Fayolle, 2nd year Master student shares her experience 👇

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Jan 2025

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Chaires d’excellence 2024: congratulations to Yasmine Belkaid

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Apr 2024

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New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to...

25

Mar 2024

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New publication – Smoking changes adaptive immunity with persistent effects

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Feb 2024

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ERC Proof of concept grant 2023: congratulations to Lucie Peduto

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Jan 2024

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Easy Panel

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Dec 2023

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New publication – Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells pro...

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Oct 2023

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New publication – Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a po...

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Aug 2023

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Ludovic Deriano laureate of the Pasteur Vallery-Radot prize 2023

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Jun 2023

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New publication – Tissue-resident memory T cells mediate mucosal immunity to recu...

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Jun 2023

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New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN...

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Jun 2023

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New publication – Stromal regulation of the intestinal barrier

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Jan 2023

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ERC Synergy grant 2022: congratulations to Caroline Demangel

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Oct 2022

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New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

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Aug 2022

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New publication – The neuropeptide VIP potentiates intestinal innate type 2 and t...

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Jul 2022

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New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibo...

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New publication – High resolution microfluidic assay and probabilistic modeling r...

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Jun 2022

About

Immune responses are highly coordinated processes that develop within complex tissue microenvironments. The research in our Department aims to uncover novel mechanisms regulating the development and functions of the immune system with the objective to delineate new strategies to fight infections, cancer and chronic inflammatory diseases.

Credits: Peduto lab, Bousso lab, Alcover lab

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The Department of Immunology is directed by Ludovic Deriano (Director) and Caroline Demangel (deputy director).

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Teams

Laboratory

Antibodies in Therapy and Pathology

Pierre Bruhns

Laboratory

Dynamics of Immune Responses

Philippe Bousso

Laboratory

Humoral Immunology

Hugo Mouquet

Laboratory

Immunobiology and Therapy

Caroline Demangel

Laboratory

Immunoregulation

Lars Rogge

Laboratory

Innate Immunity

James Di Santo

Laboratory

Genome integrity, Immunity and Cancer

Ludovic Deriano

Laboratory

Microenvironment and Immunity

Gérard Eberl

Laboratory

Stroma, Inflammation and Tissue Repair

Lucie Peduto

UTechS

Platform

UTechS Single Cell Biomarkers

Milena Hasan

Laboratory

Translational Immunology

Darragh Duffy

Group

Mucosal Inflammation and Immunity

Molly Ingersoll

Laboratory

G5

Brain-immune communication

Aleksandra Deczkowska

Laboratory

Dendritic cells and adaptive immunity

Pierre Guermonprez

Laboratory

Meta-organism

Yasmine Belkaid

Associated teams

Laboratory

G5

Microbiome-Host Interactions

Benoit Chassaing

Laboratory

Macrophages and Endothelial Cells

Elisa Gomez Perdiguero

Laboratory

Biology and Genetics of Bacterial Cell Wall

Ivo Gomperts Boneca

Laboratory

Chromatin and Infection

Mélanie Hamon

Laboratory

UMR

Biology of infection

Marc Lecuit

Laboratory

Integrative Neurobiology of Cholinergic Systems

Uwe Maskos

Laboratory

HIV, Inflammation and Viral Persistences

Michaela Muller-Trutwin

Laboratory

Immunology of Fungal Infections

Jessica Quintin

Laboratory

Viral reservoirs and immune control

Asier Sáez-Cirión

Laboratory

Virus and Immunity

Olivier Schwartz

Management

Ludovic Deriano

Head of Structure

Director

Caroline Demangel

Head of Structure

Deputy

Cécile Peltekian

Department Manager

Partners

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Featured Publications

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• 2025
  Mesquita Peixoto M, Soares-da-Silva F, Bonnet V, Zhou Y, Ronteix G, Santos RF, Mailhe MP, Nogueira G, Feng X, Pereira JP, Azzoni E, Anselmi G, de Bruijn MFTR, Perkins A, Baroud CN, Pinto-do-Ó P, Cumano A, Spatiotemporal dynamics of fetal liver hematopoietic niches., J Exp Med 2025 Feb; 222(2): .
• 2025
  Robert M, Villain E, Yatim N, Mageau A, Charles N, Culina S, Peiffer-Smadja N, Borie R, Duffy D, Sacré K, Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis: a nested case-control study in Sweden., Eur Respir J 2025 Jan; 65(1): .
• 2024
  Terroba-Navajas P, Spatola M, Chuquisana O, Joubert B, de Vries JM, Dik A, Marmolejo L, Jönsson F, Lauc G, Kovac S, Prüss H, Wiendl H, Titulaer MJ, Honnorat J, Lünemann JD, Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes., Med 2024 Oct; (): .
• 2024
  Dejoux A, Zhu Q, Ganneau C, Goff OR, Godon O, Lemaitre J, Relouzat F, Huetz F, Sokal A, Vandenberghe A, Pecalvel C, Hunault L, Derenne T, Gillis CM, Iannascoli B, Wang Y, Rose T, Mertens C, Nicaise-Roland P, , England P, Mahévas M, de Chaisemartin L, Le Grand R, Letscher H, Saul F, Pissis C, Haouz A, Reber LL, Chappert P, Jönsson F, Ebo DG, Millot GA, Bay S, Chollet-Martin S, Gouel-Chéron A, Bruhns P, Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models., Sci Transl Med 2024 Sep; 16(764): eado4463.
• 2024
  Ruggiu M, Guérin MV, Corre B, Bardou M, Alonso R, Russo E, Garcia Z, Feldmann L, Lemaître F, Dusseaux M, Grandjean CL, Bousso P, Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes., J Exp Med 2024 Apr; 221(4): .
• 2024
  Saint-André V, Charbit B, Biton A, Rouilly V, Possémé C, Bertrand A, Rotival M, Bergstedt J, Patin E, Albert ML, Quintana-Murci L, Duffy D, Smoking changes adaptive immunity with persistent effects., Nature 2024 Feb; 626(8000): 827-835.
• 2023
  Boulch M, Cazaux M, Cuffel A, Guerin MV, Garcia Z, Alonso R, Lemaître F, Beer A, Corre B, Menger L, Grandjean CL, Morin F, Thieblemont C, Caillat-Zucman S, Bousso P, Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity., Nat Cancer 2023 Jul; 4(7): 968-983.
• 2023
  Jagot F, Gaston-Breton R, Choi AJ, Pascal M, Bourhy L, Dorado-Doncel R, Conzelmann KK, Lledo PM, Lepousez G, Eberl G, The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β., Neuron 2023 May; (): .
• 2023
  Rousseau M, Lacerda Mariano L, Canton T, Ingersoll MA, Tissue-resident memory T cells mediate mucosal immunity to recurrent urinary tract infection., Sci Immunol 2023 May; 8(83): eabn4332.
• 2023
  Lamanna E, Conde E, Mougel A, Bonnefoy J, Colaone F, Godon O, Hamdi S, Kamphuis JBJ, Drouet B, Serra V, Bruhns P, Reber LL, A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice., Allergy 2023 Feb; (): .
• 2022
  Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P, Di Santo JP, Serafini N, , Inflammation triggers ILC3 patrolling of the intestinal barrier., Nat Immunol 2022 Aug; (): .
• 2022
  Travier L, Singh R, Sáenz Fernández D, Deczkowska A, , Microbial and immune factors regulate brain maintenance and aging., Curr Opin Neurobiol 2022 Jul; 76(): 102607.
• 2022
  Goncalves P, Doisne JM, Eri T, Charbit B, Bondet V, Posseme C, Llibre A, Casrouge A, Lenoir C, Neven B, Duffy D, Fischer A, Di Santo JP, Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency., Blood 2022 Apr; 139(17): 2585-2600.
• 2022
  Domenger A, Choisy C, Baron L, Mayau V, Perthame E, Deriano L, Arnulf B, Bories JC, Dadaglio G, Demangel C, , The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
• 2021
  Luzuriaga MA, Herbert FC, Brohlin OR, Gadhvi J, Howlett T, Shahrivarkevishahi A, Wijesundara YH, Venkitapathi S, Veera K, Ehrman R, Benjamin CE, Popal S, Burton MD, Ingersoll MA, De Nisco NJ, Gassensmith JJ, , Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection., ACS Nano 2021 Sep; (): .
• 2021
  Smith N, Goncalves P, Charbit B, Grzelak L, Beretta M, Planchais C, Bruel T, Rouilly V, Bondet V, Hadjadj J, Yatim N, Pere H, Merkling SH, Ghozlane A, Kernéis S, Rieux-Laucat F, Terrier B, Schwartz O, Mouquet H, Duffy D, Di Santo JP, , Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection., Nat Immunol 2021 Sep; 22(11):1428-1439.
• 2021
  Yatim N, Boussier J, Tetu P, Smith N, Bruel T, Charbit B, Barnabei L, Corneau A, Da Meda L, Allayous C, Baroudjian B, Jebali M, Herms F, Grzelak L, Staropoli I, Calmettes V, Hadjadj J, Peyrony O, Cassius C, LeGoff J, Kramkimel N, Aractingi S, Fontes M, Blanc C, Rieux-Laucat F, Schwartz O, Terrier B, Duffy D, Lebbé C, , Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection., Sci Adv 2021 08; 7(34): .
• 2021
  Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, Colaone F, Hamdi S, Houmadi R, Loste A, Kamphuis JBJ, Huetz F, Guilleminault L, Gaudenzio N, Mougel A, Hardy D, Snouwaert JN, Koller BH, Serra V, Bruhns P, Grouard-Vogel G, Reber LL, , Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice., Nat Commun 2021 May; 12(1): 2574.
• 2020
  Chevalier G, Siopi E, Guenin-Macé L, Pascal M, Laval T, Rifflet A, Boneca IG, Demangel C, Colsch B, Pruvost A, Chu-Van E, Messager A, Leulier F, Lepousez G, Eberl G, Lledo PM, , Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
• 2020
  Rousseau M, O'Brien CJO, Antequera E, Zdimerova H, Cansever D, Canton T, Zychlinsky Scharff A & Ingersoll MA, Identification of sex differences in tumor-specific T cell infiltration in bladder tumor-bearing mice treated with BCG immunotherapy, Bladder Cancer, 2020 Oct.
• 2020
  Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J, , , , , , , , , , , Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL, Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 Oct; 370(6515): .
• 2020
  Yu W, Lescale C, Babin L, Bedora-Faure M, Lenden-Hasse H, Baron L, Demangel C, Yelamos J, Brunet E, Deriano L, , Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
• 2020
  Guenin-Macé L, Morel JD, Doisne JM, Schiavo A, Boulet L, Mayau V, Goncalves P, Duchatelet S, Hovnanian A, Bondet V, Duffy D, Ungeheuer MN, Delage M, Nassif A, Di Santo JP, Demangel C, , Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
• 2020
  Elsaid R, Meunier S, Burlen-Defranoux O, Soares-da-Silva F, Perchet T, Iturri L, Freyer L, Vieira P, Pereira P, Golub R, Bandeira A, Gomez Perdiguero E, Cumano A, , A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner., Blood 2021 Feb 25; 137(8): 1024-1036.
• 2020
  Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P, Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells., Immunity 2020 Aug; 53(2): 335-352.e8.
• 2020
  Hadjadj J, Yatim N, Barnabei L, Corneau A, Boussier J, Smith N, Péré H, Charbit B, Bondet V, Chenevier-Gobeaux C, Breillat P, Carlier N, Gauzit R, Morbieu C, Pène F, Marin N, Roche N, Szwebel TA, Merkling SH, Treluyer JM, Veyer D, Mouthon L, Blanc C, Tharaux PL, Rozenberg F, Fischer A, Duffy D, Rieux-Laucat F, Kernéis S, Terrier B, , Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients., Science 2020 08; 369(6504): 718-724.
• 2020
  Juzans M, Cuche C, Rose T, Mastrogiovanni M, Bochet P, Di Bartolo V, Alcover A, , Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions., Immunohorizons 2020 06; 4(6): 363-381.
• 2020
  Hehle V, Beretta M, Bourgine M, Ait-Goughoulte M, Planchais C, Morisse S, Vesin B, Lorin V, Hieu T, Stauffer A, Fiquet O, Dimitrov JD, Michel ML, Ungeheuer MN, Sureau C, Pol S, Di Santo JP, Strick-Marchand H, Pelletier N, Mouquet H, , Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers., J. Exp. Med. 2020 ; 217(10): .
• 2020
  Goncalves P, Charbit B, Lenoir C, , Duffy D, Fischer A, Di Santo JP, , Antibody-coated microbiota in nasopharynx of healthy individuals and IVIg-treated patients with hypogammaglobulinemia., J Allergy Clin Immunol 2020 06; 145(6): 1686-1690.e4.
• 2020
  Benabid A, Peduto L, Mesenchymal perivascular cells in immunity and disease, Curr. Opin. Immunol. 2020 May;64:50-55.
• 2020
  Allweiss L, Strick-Marchand H, In-vitro and in-vivo models for hepatitis B cure research., Curr Opin HIV AIDS 2020 May; 15(3): 173-179.
• 2020
  Gérard A, Woolfe A, Mottet G, Reichen M, Castrillon C, Menrath V, Ellouze S, Poitou A, Doineau R, Briseno-Roa L, Canales-Herrerias P, Mary P, Rose G, Ortega C, Delincé M, Essono S, Jia B, Iannascoli B, Richard-Le Goff O, Kumar R, Stewart SN, Pousse Y, Shen B, Grosselin K, Saudemont B, Sautel-Caillé A, Godina A, McNamara S, Eyer K, Millot GA, Baudry J, England P, Nizak C, Jensen A, Griffiths AD, Bruhns P, Brenan C, High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics, Nat. Biotechnol. 2020 Mar;.
• 2020
  Ronan Thibaut, Pierre Bost, Idan Milo, Marine Cazaux, Fabrice Lemaître, Zacarias Garcia, Ido Amit, Béatrice Breart, Clémence Cournuot, Benno Schwikowski, Philippe Bousso, Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment, Nature Cancer 2020 Mar 1(3):302-314.
• 2020
  Li Z, Rotival M, Patin E, Michel F, Pellegrini S, , Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage., PLoS One 2020 ; 15(1): e0225289.
• 2018
  Milo I, Bedora-Faure M, Garcia Z, Thibaut R, Périé L, Shakhar G, Deriano L, Bousso P, The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol 2018 Nov;3(29).
• 2018
  Dev H, Chiang TW#, Lescale C#, de Krijger I#, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L*, Jacobs JJL*, Galanty Y*, Jackson SP.*, Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells., Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18..
• 2018
  Li Y, Masse-Ranson G, Garcia Z, Bruel T, Kök A, Strick-Marchand H, Jouvion G, Serafini N, Lim AI, Dusseaux M, Hieu T, Bourgade F, Toubert A, Finke D, Schwartz O, Bousso P, Mouquet H, Di Santo JP, , A human immune system mouse model with robust lymph node development., Nat Methods 2018 08; 15(8): 623-630.
• 2017
  Kremsdorf D, Strick-Marchand H, Modeling hepatitis virus infections and treatment strategies in humanized mice, Curr Opin Virol 2017 Aug;25:119-125.
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  View full list of featured publications

Pictures & Media

Immune awakening
At the heart of immunity – Yasmine Belkaid
Why is your gut microbiota so important?
Philippe Bousso: harnessing immune responses to combat cancer
Caroline Demangel – an ambitious and enterprising scientist
A team tackling the mysteries of the microbiota, the brain and the immune system
Blood cancer: a treatment to reprogram cancer cell death and trigger the immune system
Immunotherapy for blood cancer: remote destruction of tumor cells demonstrated
SpikImm announces the clinical trials start for SPK001, its monoclonal antibody against SARS-CoV-2
Understanding the Immune System’s Role in Curing Diseases

Contact

Marie-Laure Goupil – Department of Immunology / Email: marie-laure.goupil@pasteur.fr Institut Pasteur 28 rue du Dr Roux, 75015 Paris.

Cécile Peltekian – Department of Immunology / Email: cecile.peltekian@pasteur.fr Institut Pasteur 28 rue du Dr Roux, 75015 Paris.