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© Bruno Dupuy, Claire Morvan, Institut Pasteur
Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile
Publication : Research in microbiology

Integration of metabolism and virulence in Clostridium difficile

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in microbiology - 15 Oct 2014

Bouillaut L, Dubois T, Sonenshein AL, Dupuy B

Link to Pubmed [PMID] – 25445566

Res. Microbiol. 2015 May;166(4):375-83

Synthesis of the major toxin proteins of the diarrheal pathogen, Clostridium difficile, is dependent on the activity of TcdR, an initiation (sigma) factor of RNA polymerase. The synthesis of TcdR and the activation of toxin gene expression are responsive to multiple components in the bacterium’s nutritional environment, such as the presence of certain sugars, amino acids, and fatty acids. This review summarizes current knowledge about the mechanisms responsible for repression of toxin synthesis when glucose or branched-chain amino acids or proline are in excess and the pathways that lead to synthesis of butyrate, an activator of toxin synthesis. The regulatory proteins implicated in these mechanisms also play key roles in modulating bacterial metabolic pathways, suggesting that C. difficile pathogenesis is intimately connected to the bacterium’s metabolic state.

http://www.ncbi.nlm.nih.gov/pubmed/25445566