c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficileIn their
In their latest publication, Oberkampf et al. (Pathogenesis of microbial anaerobes Unit) investigated the role of the second messenger c-di-AMP in various homeostatic and stress responses in bacteria.
Oberkampf et al. have identified it as a mediator of osmotic stress and bile salt resistance in the opportunistic pathogen Clostridioides difficile, with additional roles in cell wall homeostasis and biofilm formation.