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© Bruno Dupuy, Claire Morvan, Institut Pasteur
Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile
Publication : BMC microbiology

The LexA regulated genes of the Clostridium difficile

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC microbiology - 08 Apr 2014

Walter BM, Rupnik M, Hodnik V, Anderluh G, Dupuy B, Paulič N, Žgur-Bertok D, Butala M

Link to Pubmed [PMID] – 24713082

BMC Microbiol. 2014;14:88

The SOS response including two main proteins LexA and RecA, maintains the integrity of bacterial genomes after DNA damage due to metabolic or environmental assaults. Additionally, derepression of LexA-regulated genes can result in mutations, genetic exchange and expression of virulence factors. Here we describe the first comprehensive description of the in silico LexA regulon in Clostridium difficile, an important human pathogen.

http://www.ncbi.nlm.nih.gov/pubmed/24713082