Ligne de temps
Bruno Dupuy
Responsable de Structure
19 janv. 2024
01 janv. 2024
publication
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology.
Lire plus01 déc. 2023
publication
Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile.
Lire plus15 sept. 2023
26 juin 2023
11 mai 2023
publication
The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile.
Lire plus01 mai 2023
publication
Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling.
Lire plus13 sept. 2022
news
Highlighted paper: “c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile”, Oberkampf et al. Science Signalling; Sept 2022; Pathogenesis of Bacterial anaerobes Unit; Microbiology Dpt.
Lire plus06 sept. 2022
publication
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile.
Lire plus01 mai 2022
publication
Core-, pan- and accessory genome analyses of Clostridium neonatale: insights into genetic diversity.
Lire plus01 avr. 2022
15 févr. 2022
publication
Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation.
Lire plus08 févr. 2022
publication
A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridiumsordellii.
Lire plus20 déc. 2021
news
Highlighted publication: “In vivo commensal control of Clostridioides difficile virulence” Girinathan et al., Cell Host ; Microbes, Pathenogenesis of Bacterial Anaerobes team
Lire plus10 nov. 2021
publication
Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile.
Lire plus10 nov. 2021
10 sept. 2021
publication
Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections.
Lire plus21 juin 2021
publication
Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile.
Lire plus18 mai 2021
publication
Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile.
Lire plus17 mars 2021
publication
Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones.
Lire plus25 févr. 2021
publication
Identification of RNAs bound by Hfq reveals widespread RNA partners and a sporulation regulator in the human pathogen Clostridioides difficile.
Lire plus27 nov. 2020
publication
Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile.
Lire plus08 sept. 2020
publication
How the Anaerobic Enteropathogen Clostridioides difficile Tolerates Low O2 Tensions.
Lire plus25 août 2020
publication
Clostridioides difficile para-Cresol Production Is Induced by the Precursor para-Hydroxyphenylacetate.
Lire plus01 janv. 2020
publication
Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile.
Lire plus11 déc. 2019
publication
An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
Lire plus23 juil. 2019
publication
The Ser/Thr Kinase PrkC Participates in Cell Wall Homeostasis and Antimicrobial Resistance in Clostridium difficile.
Lire plus09 mai 2019
29 avr. 2019
publication
The σ signalling activation pathway in the enteropathogen Clostridioides difficile
Lire plus18 mars 2019
publication
Role of the global regulator Rex in control of NAD -regeneration in Clostridioides (Clostridium) difficile
Lire plus25 févr. 2019
21 févr. 2019
20 août 2018
publication
Clostridium difficile biofilm: remodeling metabolism and cell surface to build a sparse and heterogeneously aggregated architecture
Lire plus29 juil. 2018
publication
A microfluidic fluidized bed to capture, amplify and detect bacteria from raw samples
Lire plus12 juin 2018
publication
Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in
Lire plus28 mars 2018
publication
Micro-nano-bio acoustic system for the detection of foodborne pathogens in real samples
Lire plus12 mars 2018
26 févr. 2018
publication
Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile
Lire plus17 nov. 2017
publication
High prevalence and genetic diversity of large phiCD211/phiCDIF1296T-like prophages in Clostridioides difficile
Lire plus04 sept. 2017
publication
Advanced immunocapture of milk-borne Salmonella by microfluidic magnetically stabilized fluidized bed
Lire plus21 mars 2017
publication
The alternative sigma factor σ plays a crucial role in adaptive strategies of Clostridium difficile during gut infection
Lire plus15 févr. 2017
publication
Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291
Lire plus10 oct. 2016
publication
A new microfluidic approach for the one-step capture, amplification and label-free quantification of bacteria from raw samples
Lire plus23 sept. 2016
project
Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains
Lire plus22 sept. 2016
21 sept. 2016
publication
What’s a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives
Lire plus15 sept. 2016
publication
A Recombination Directionality Factor Controls the Cell Type-Specific Activation of σK and the Fidelity of Spore Development in Clostridium difficile
Lire plus31 août 2016
publication
Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes.
Lire plus21 juil. 2016
publication
Control of Clostridium difficile Physiopathology in Response to Cysteine Availability
Lire plus28 juin 2016
publication
Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis
Lire plus14 mai 2016
26 mars 2016
publication
Cpe1786/IscR of Clostridium perfringens represses expression of genes involved in Fe-S cluster biogenesis
Lire plus01 janv. 2016
publication
Micro-Nano-Bio Diagnostic System for Food Pathogen Detection Revolutionizes Food Safety Management & Protects Consumers Health
Lire plus11 nov. 2015
publication
Plasma nanotextured polymeric lab-on-a-chip for highly efficient bacteria capture and lysis
Lire plus09 nov. 2015
14 oct. 2015
project
Biology of anaerobic biofilm formed by Clostridium difficile and their role in infections
Lire plus13 oct. 2015
project
The regulatory network of sporulation and spore morphogenesis in Clostridium difficile
Lire plus01 sept. 2015
17 août 2015
11 mai 2015
10 janv. 2015
publication
Repressor activity of the RpoS/σS-dependent RNA polymerase requires DNA binding
Lire plus01 déc. 2014
publication
Inter- and intraspecies transfer of a Clostridium difficile conjugative transposon conferring resistance to MLSB
Lire plus15 oct. 2014
15 sept. 2014
30 juin 2014
publication
Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile
Lire plus09 juin 2014
publication
Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole
Lire plus19 mai 2014
publication
The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection
Lire plus08 mai 2014
publication
Expanding the RpoS/σS-network by RNA sequencing and identification of σS-controlled small RNAs in Salmonella
Lire plus08 avr. 2014
10 févr. 2014
publication
COV2HTML: a visualization and analysis tool of bacterial next generation sequencing (NGS) data for postgenomics life scientists
Lire plus23 janv. 2014
publication
Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation
Lire plus16 déc. 2013
publication
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR
Lire plus03 oct. 2013
publication
Genome-wide analysis of cell type-specific gene transcription during spore formation in Clostridium difficile
Lire plus16 sept. 2013
09 mai 2013
publication
Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile
Lire plus18 sept. 2012
publication
Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Lire plus07 juin 2012
publication
Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE
Lire plus13 oct. 2011
publication
The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile
Lire plus13 avr. 2011
28 déc. 2010
07 sept. 2010
publication
Global regulation of gene expression in response to cysteine availability in Clostridium perfringens
Lire plus26 févr. 2010
publication
Characterization of Acp, a peptidoglycan hydrolase of Clostridium perfringens with N-acetylglucosaminidase activity that is implicated in cell separation and stress-induced autolysis
Lire plus01 janv. 2010
publication
Molecular methods to study transcriptional regulation of Clostridium difficile toxin genes
Lire plus05 oct. 2009
publication
Effects of subinhibitory concentrations of antibiotics on colonization factor expression by moxifloxacin-susceptible and moxifloxacin-resistant Clostridium difficile strains
Lire plus23 sept. 2009
17 août 2009
01 juin 2008
01 juin 2007
publication
Clostridium difficile toxin expression is inhibited by the novel regulator TcdC
Lire plus25 juin 2006
publication
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Lire plus01 mai 2006
publication
Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors
Lire plus01 janv. 2006
publication
Isolation of RNA polymerase from Clostridium difficile and characterization of glutamate dehydrogenase and rRNA gene promoters in vitro and in vivo
Lire plus29 déc. 2005
publication
Regulation of toxin and bacteriocin synthesis in Clostridium species by a new subgroup of RNA polymerase sigma-factors
Lire plus01 févr. 2005
01 févr. 2005
publication
Transcription activation of a UV-inducible Clostridium perfringens bacteriocin gene by a novel sigma factor
Lire plus01 janv. 2005
publication
BotR/A and TetR are alternative RNA polymerase sigma factors controlling the expression of the neurotoxin and associated protein genes in Clostridium botulinum type A and Clostridium tetani
Lire plus01 juin 2004
publication
The spatial organization of the VirR boxes is critical for VirR-mediated expression of the perfringolysin O gene, pfoA, from Clostridium perfringens
Lire plus01 avr. 2004
publication
Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani
Lire plus01 avr. 2003
publication
Expression of Clostridium difficile toxins A and B and their sigma factor TcdD is controlled by temperature
Lire plus01 nov. 2002
publication
Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression
Lire plus24 avr. 2001
publication
Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor
Lire plus01 janv. 1998
01 juin 1997
26 juil. 1996
publication
Genome mapping of Clostridium perfringens strains with I-CeuI shows many virulence genes to be plasmid-borne
Lire plus01 oct. 1995
publication
Rapid expansion of the physical and genetic map of the chromosome of Clostridium perfringens CPN50
Lire plus01 mars 1994
publication
Type IV prepilin peptidase gene of Neisseria gonorrhoeae MS11: presence of a related gene in other piliated and nonpiliated Neisseria strains
Lire plus01 sept. 1992
publication
Role of pilA, an essential regulatory gene of Neisseria gonorrhoeae, in the stress response
Lire plus01 juil. 1992
publication
PulO, a component of the pullulanase secretion pathway of Klebsiella oxytoca, correctly and efficiently processes gonococcal type IV prepilin in Escherichia coli
Lire plus01 mars 1992
publication
An enzyme with type IV prepilin peptidase activity is required to process components of the general extracellular protein secretion pathway of Klebsiella oxytoca
Lire plus01 déc. 1991
01 janv. 1991
publication