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© Bruno Dupuy, Claire Morvan, Institut Pasteur
Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile
Publication : NPJ biofilms and microbiomes

A microbiota-generated bile salt induces biofilm formation in

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in NPJ biofilms and microbiomes - 09 May 2019

Dubois T, Tremblay YDN, Hamiot A, Martin-Verstraete I, Deschamps J, Monot M, Briandet R, Dupuy B

Link to Pubmed [PMID] – 31098293

NPJ Biofilms Microbiomes 2019;5:14

is a major cause of nosocomial infections. Bacterial persistence in the gut is responsible for infection relapse; sporulation and other unidentified mechanisms contribute to this process. Intestinal bile salts cholate and deoxycholate stimulate spore germination, while deoxycholate kills vegetative cells. Here, we report that sub-lethal concentrations of deoxycholate stimulate biofilm formation, which protects . from antimicrobial compounds. The biofilm matrix is composed of extracellular DNA and proteinaceous factors that promote biofilm stability. Transcriptomic analysis indicates that deoxycholate induces metabolic pathways and cell envelope reorganization, and represses toxin and spore production. In support of the transcriptomic analysis, we show that global metabolic regulators and an uncharacterized lipoprotein contribute to deoxycholate-induced biofilm formation. Finally, enhances biofilm formation of by converting cholate into deoxycholate. Together, our results suggest that deoxycholate is an intestinal signal that induces persistence and may increase the risk of relapse.

https://www.ncbi.nlm.nih.gov/pubmed/31098293