Timeline
Carmen Buchrieser
Head of Structure
18 Mar 2024
14 Mar 2024
publication
The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors.
Read more29 Jan 2024
event
Microbiology department seminar: Elisabeth Hartland (Monash University, Australia): “Bacterial effector proteins as tools for understanding host-pathogen interactions” ; Friday 16 February @11.30am ; Auditorium F.Jacob
Read more22 Dec 2023
project
From the source to the user end: deciphering the impact of microbiome and water parameters on opportunistic waterborne pathogens (MicroPathWater)
Read more03 Nov 2023
31 Oct 2023
publication
Modelling Legionnaires’ disease: Lessons learned from invertebrate and vertebrate animal models.
Read more05 Oct 2023
publication
The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Read more18 Sep 2023
event
Joint Microbiology, BCI, and Structural Biology and Chemistry Departments seminar: Melanie OTT (UCSF, USA) ; “Understanding SARS-CoV-2 Variants through Reverse Genetics” ; Wenesday 27 September @2.00pm; Jules Bordet room
Read more12 Sep 2023
17 Aug 2023
publication
The respiratory tract microbiome, the pathogen load, and clinical interventions define severity of bacterial pneumonia.
Read more30 May 2023
08 May 2023
publication
Hiding in the yolk: A unique feature of Legionella pneumophila infection of zebrafish.
Read more14 Apr 2023
05 Apr 2023
event
Symposium on Microbial Extracellular Vesicles ; June 15th, 2023 ; Auditorium François Jacob
Read more17 Mar 2023
publication
High-content assay to measure mitochondrial function and bacterial vacuole size in infected human primary macrophages.
Read more06 Jan 2023
publication
Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins.
Read more01 Jan 2023
17 Nov 2022
publication
Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 in patients receiving monoclonal antibodies.
Read more15 Sep 2022
publication
Chromosome-scale assemblies of Acanthamoeba castellanii genomes provide insights into Legionella pneumophila infection-related chromatin reorganization.
Read more10 Aug 2022
22 Jul 2022
project
Deciphering the virulence of Legionella pneumophila in vivo in the zebrafish model
Read more15 Jul 2022
publication
Genomic erosion and horizontal gene transfer shape functional differences of the ExlA toxin in Pseudomonas spp.
Read more24 Jun 2022
project
Investigation how eukaryotic domain capture might work: the evolution of a bacterial effector
Read more24 Jun 2022
project
Biogenesis, trafficking, and roles of Legionella pneumophila extracellular vesicles during infection (BioEV)
Read more04 Apr 2022
01 Mar 2022
18 Feb 2022
news
Legionellosis: a novel mechanism by which the bacterium Legionella pneumophila regulates the immune response of its host cells
Read more16 Feb 2022
publication
The evolution and role of eukaryotic-like domains in environmental intracellular bacteria: the battle with a eukaryotic cell.
Read more09 Feb 2022
publication
Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response.
Read more13 Jan 2022
news
The bacterium causing legionellosis modifies the electrochemical potential of host mitochondria to better replicate
Read more09 Dec 2021
publication
Reverting the mode of action of the mitochondrial F O F 1-ATPase by Legionella pneumophila preserves its replication niche
Read more29 Nov 2021
publication
Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics
Read more22 Oct 2021
12 Jan 2021
01 Jan 2021
publication
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Read more06 Oct 2020
publication
Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella.
Read more05 Oct 2020
27 Jul 2020
24 Jul 2020
publication
Metagenomic approaches in microbial ecology: an update on whole-genome and marker gene sequencing analyses.
Read more24 May 2020
publication
Danger-associated Metabolic Modifications During Bacterial Infection of Macrophages
Read more20 May 2020
publication
Persistent Legionnaires’ Disease and Associated Antibiotic Treatment Engender a Highly Disturbed Pulmonary Microbiome Enriched in Opportunistic Microorganisms
Read more24 Mar 2020
publication
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Read more01 Mar 2020
24 Jan 2020
publication
Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella.
Read more08 Jan 2020
event
Soutenance HDR “Immunometabolic interactions of human cells and intracellular bacteria: a new way to tackle infection” – Département Microbiologie – Pedro Escoll Guerrero
Read more18 Dec 2019
30 Aug 2019
29 Aug 2019
27 Aug 2019
publication
Evolutionary dissection of the Dot/Icm system based on comparative genomics of 58 Legionella species
Read more21 Aug 2019
publication
A Comprehensive Review on the Manipulation of the Sphingolipid Pathway by Pathogenic Bacteria
Read more20 May 2019
publication
Intracellular parasitism, the driving force of evolution of Legionella pneumophila and the genus Legionella.
Read more08 Mar 2019
20 Feb 2019
05 Feb 2019
publication
More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells.
Read more31 Jan 2019
08 Jan 2019
publication
The pleotropic Legionella transcription factor LvbR links the Lqs and c-di-GMP regulatory networks to control biofilm architecture and virulence
Read more01 Jan 2019
01 Jan 2019
publication
Analysis of the Pulmonary Microbiome Composition of Legionella pneumophila-Infected Patients
Read more01 Jan 2019
06 Dec 2018
01 Sep 2018
publication
Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL.
Read more04 May 2018
publication
The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection
Read more14 Apr 2018
publication
Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg-like metabolism?
Read more01 Feb 2018
publication
Editorial overview: Host-pathogen interactions shaped through evolutionary and regulatory processes
Read more30 Jan 2018
19 Jan 2018
publication
The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism
Read more14 Dec 2017
07 Nov 2017
publication
Legionella pneumophila CsrA regulates a metabolic switch from amino acid to glycerolipid metabolism.
Read more06 Sep 2017
31 Aug 2017
publication
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages
Read more26 Jun 2017
publication
Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila
Read more23 May 2017
23 May 2017
event
“A matter of fat: bioactive lipids at the host-mycobacteria interface” – Caroline Demangel
Read more14 Apr 2017
event
« Joint analysis of multiple phenotypes using GWAS summary statistics» by Hugues ASCHARD
Read more13 Apr 2017
06 Apr 2017
06 Apr 2017
event
EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections
Read more23 Mar 2017
01 Feb 2017
publication
The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system.
Read more10 Jan 2017
publication
A Unique cis-Encoded Small Noncoding RNA Is Regulating Legionella pneumophila Hfq Expression in a Life Cycle-Dependent Manner
Read more01 Jan 2017
27 Dec 2016
publication
MAMs are attractive targets for bacterial repurposing of the host cell: MAM-functions might be key for undermining an infected cell
Read more08 Dec 2016
30 Nov 2016
publication
Rapid detection and evolutionary analysis of Legionella pneumophila serogroup 1 sequence type 47
Read more01 Nov 2016
publication
Multiple major disease-associated clones of Legionella pneumophila have emerged recently and independently.
Read more18 May 2016
publication
Legionella pneumophila restrains autophagy by modulating the host’s sphingolipid metabolism
Read more13 May 2016
21 Mar 2016
publication
Environmental treasures: co-isolation of the first marine Chlamydiae and its protozoan host
Read more03 Mar 2016
publication
Modulation of Host Autophagy during Bacterial Infection: Sabotaging Host Munitions for Pathogen Nutrition
Read more03 Feb 2016
news
Legionella pneumophila: identification of a new strategy to counteract the antibacterial response of the host cell
Read more01 Feb 2016
publication
The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signalling and gene expression of Legionella pneumophila
Read more01 Feb 2016
publication
Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy
Read more01 Jan 2016
publication
Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy
Read more02 Dec 2015
01 Oct 2015
publication
Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery.
Read more08 Sep 2015
01 Aug 2015
publication
Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones
Read more10 Jun 2015
11 May 2015
01 May 2015
publication
Small RNAs, 5′ UTR elements and RNA-binding proteins in intracellular bacteria: impact on metabolism and virulence
Read more28 Jan 2015
publication
Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Read more15 Sep 2014
publication
IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages
Read more04 Aug 2014
publication
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Read more08 Jul 2014
publication
Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell
Read more18 Oct 2013
19 Aug 2013
publication
The Legionella pneumophila kai operon is implicated in stress response and confers fitness in competitive environments
Read more11 Jul 2013
publication
Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues
Read more01 Jun 2013
publication
Genome dynamics in Legionella: the basis of versatility and adaptation to intracellular replication.
Read more17 Apr 2013
news
Légionellose : reprogrammation inédite des cellules hôtes à l’avantage de la bactérie Legionella pneumophila
Read more17 Apr 2013
publication
Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication
Read more14 Jan 2013
publication
Nicotinic acid modulates Legionella pneumophila gene expression and induces virulence traits
Read more01 Jan 2013
publication
From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts.
Read more01 Jan 2013
01 Jan 2013
publication
cDNA library construction for next-generation sequencing to determine the transcriptional landscape of Legionella pneumophila
Read more01 Jan 2013
publication
Induction of competence for natural transformation in Legionella pneumophila and exploitation for mutant construction
Read more04 Oct 2012
publication
The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit
Read more15 Jul 2012
publication
Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila.
Read more24 Apr 2012
publication
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes
Read more01 Apr 2012
publication
Deep sequencing defines the transcriptional map of L. pneumophila and identifies growth phase-dependent regulated ncRNAs implicated in virulence
Read more01 Mar 2012
publication
Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy
Read more27 Nov 2011
23 Oct 2011
publication
Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection
Read more12 Oct 2011
01 Feb 2011
publication
GamA is a eukaryotic-like glucoamylase responsible for glycogen- and starch-degrading activity of Legionella pneumophila.
Read more20 Dec 2010
publication
Fatty acid composition modulates sensitivity of Legionella pneumophila to warnericin RK, an antimicrobial peptide
Read more06 Dec 2010
26 May 2010
04 May 2010
publication
Isotopologue profiling of Legionella pneumophila: role of serine and glucose as carbon substrates
Read more29 Mar 2010
publication
The Legionella pneumophila LetA/LetS two-component system exhibits rheostat-like behavior
Read more25 Mar 2010
publication
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication
Read more28 Feb 2010
10 Feb 2010
publication
Update on Legionnaires’ disease: pathogenesis, epidemiology, detection and control
Read more09 Feb 2010
publication
The autoinducer synthase LqsA and putative sensor kinase LqsS regulate phagocyte interactions, extracellular filaments and a genomic island of Legionella pneumophila
Read more13 Nov 2009
publication
Control of flagellar gene regulation in Legionella pneumophila and its relation to growth phase
Read more09 Oct 2009
publication
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis
Read more24 Sep 2009
01 Sep 2009
01 Aug 2009
publication
Molecular mimicry: an important virulence strategy employed by Legionella pneumophila to subvert host functions.
Read more23 Jun 2009
publication
Listeria monocytogenes L-forms respond to cell wall deficiency by modifying gene expression and the mode of division
Read more29 May 2009
publication
In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection
Read more01 May 2009
publication
Two small ncRNAs jointly govern virulence and transmission in Legionella pneumophila
Read more01 Apr 2009
publication
Genome sequence of Vibrio splendidus: an abundant planctonic marine species with a large genotypic diversity
Read more19 Sep 2008
publication
Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactions
Read more21 Apr 2008
14 Apr 2008
publication
The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule
Read more06 Feb 2008
publication
Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse species
Read more18 Jan 2008
01 Jan 2008
publication
Transcriptional profiling of Legionella pneumophila biofilm cells and the influence of iron on biofilm formation
Read more01 Oct 2007
publication
Comparative transcriptome analysis of Listeria monocytogenes strains of the two major lineages reveals differences in virulence, cell wall, and stress response.
Read more05 Jul 2007
publication
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA
Read more21 May 2007
publication
Legionella pneumophila adaptation to intracellular life and the host response: clues from genomics and transcriptomics
Read more07 May 2007
06 May 2007
30 Apr 2007
publication
Legionella pathogenicity: genome structure, regulatory networks and the host cell response
Read more12 Jan 2007
publication
The presence of the internalin gene in natural atypically hemolytic Listeria innocua strains suggests descent from L. monocytogenes
Read more01 Jan 2007
26 Dec 2006
publication
Genetic diversity of Listeria monocytogenes recovered from infected persons and pork, seafood and dairy products on retail sale in France during 2000 and 2001
Read more01 Dec 2006
publication
Growth-phase-dependent mobility of the lvh-encoding region in Legionella pneumophila strain Paris
Read more16 Oct 2006
publication
Specific regions of genome plasticity and genetic diversity of the commensal Escherichia coli A0 34/86
Read more26 Sep 2006
publication
Use of DNA arrays for the analysis of outbreak-related strains of Listeria monocytogenes
Read more15 Aug 2006
publication
How to become a uropathogen: comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains
Read more11 Aug 2006
01 Aug 2006
publication
Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila
Read more19 Jan 2006
06 Jan 2006
publication
Adaptation of Legionella pneumophila to the host environment: role of protein secretion, effectors and eukaryotic-like proteins
Read more01 May 2005
01 Feb 2005
publication
Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83 : K24 : H31).
Read more01 Jan 2005
publication
How seryl-phosphorylated HPr inhibits PrfA, a transcription activator of Listeria monocytogenes virulence genes
Read more03 Oct 2004
publication
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity
Read more01 Oct 2004
publication
The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536
Read more01 Aug 2004
01 May 2004
publication
Global analysis of gene expression in an rpoN mutant of Listeria monocytogenes
Read more01 May 2004
publication
DNA macroarray for identification and typing of Staphylococcus aureus isolates
Read more01 Apr 2004
01 Feb 2004
publication
Macro-array and bioinformatic analyses reveal mycobacterial ‘core’ genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex
Read more01 Feb 2004
publication
New aspects regarding evolution and virulence of Listeria monocytogenes revealed by comparative genomics and DNA arrays
Read more05 Oct 2003
publication
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens
Read more01 Apr 2003
publication
Comparison of the genome sequences of Listeria monocytogenes and Listeria innocua: clues for evolution and pathogenicity
Read more01 Mar 2003
publication
Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
Read more01 Mar 2003
publication
Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA
Read more01 Sep 2002
publication
Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease
Read more01 Aug 2002
publication