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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annual review of pathology - 24 Jan 2020

Mondino S, Schmidt S, Rolando M, Escoll P, Gomez-Valero L, Buchrieser C,

Link to Pubmed [PMID] – 31657966

Link to DOI [DOI] – 10.1146/annurev-pathmechdis-012419-032742

Annu Rev Pathol 2020 01; 15(): 439-466

Legionella species are environmental gram-negative bacteria able to cause a severe form of pneumonia in humans known as Legionnaires’ disease. Since the identification of Legionella pneumophila in 1977, four decades of research on Legionella biology and Legionnaires’ disease have brought important insights into the biology of the bacteria and the molecular mechanisms that these intracellular pathogens use to cause disease in humans. Nowadays, Legionella species constitute a remarkable model of bacterial adaptation, with a genus genome shaped by their close coevolution with amoebae and an ability to exploit many hosts and signaling pathways through the secretion of a myriad of effector proteins, many of which have a eukaryotic origin. This review aims to discuss current knowledge of Legionella infection mechanisms and future research directions to be taken that might answer the many remaining open questions. This research will without a doubt be a terrific scientific journey worth taking.

https://pubmed.ncbi.nlm.nih.gov/31657966