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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 09 Feb 2022

Sahr T, Escoll P, Rusniok C, Bui S, Pehau-Arnaudet G, Lavieu G, Buchrieser C,

Link to Pubmed [PMID] – 35140216

Link to DOI – 10.1038/s41467-022-28454-x

Nat Commun 2022 Feb; 13(1): 762

Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe form of pneumonia in humans, a phenotype evolved through interactions with aquatic protozoa in the environment. Here, we show that L. pneumophila uses extracellular vesicles to translocate bacterial small RNAs (sRNAs) into host cells that act on host defence signalling pathways. The bacterial sRNA RsmY binds to the UTR of ddx58 (RIG-I encoding gene) and cRel, while tRNA-Phe binds ddx58 and irak1 collectively reducing expression of RIG-I, IRAK1 and cRel, with subsequent downregulation of IFN-β. Thus, RsmY and tRNA-Phe are bacterial trans-kingdom regulatory RNAs downregulating selected sensor and regulator proteins of the host cell innate immune response. This miRNA-like regulation of the expression of key sensors and regulators of immunity is a feature of L. pneumophila host-pathogen communication and likely represents a general mechanism employed by bacteria that interact with eukaryotic hosts.

Institut Pasteur: https://www.pasteur.fr/en/home/press-area/press-documents/legionellosis-novel-mechanism-which-bacterium-legionella-pneumophila-regulates-immune-response-its

Medical Express: https://medicalxpress.com/news/2022-02-mechanism-bacterium-legionella-pneumophila-immune.html

Science Daily: https://www.sciencedaily.com/releases/2022/02/220218100648.htm

Verve Times: https://vervetimes.com/a-novel-mechanism-by-which-the-bacterium-legionella-pneumophila-regulates-the-immune-response-of-its-host-cells-sciencedaily/

https://pubmed.ncbi.nlm.nih.gov/35140216