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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication :

Danger-associated Metabolic Modifications During Bacterial Infection of Macrophages

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 24 May 2020

Mariatou Dramé, Carmen Buchrieser, Pedro Escoll

Int. Immunol. 2020 May

Pubmed link: 32441740

Abstract

In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their benefit, infected host cells might sense bacteria-induced metabolic alterations and activate immune reactions. Here we report the known metabolic interactions that occur during infection of macrophages by intracellular bacteria and discuss the possible emergence of DAMMs upon bacteria-induced alterations of cellular metabolism.

Keywords: DAMM; OXPHOS; glycolysis; immunometabolism; intracellular bacteria.