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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : International review of cell and molecular biology

Legionella and mitochondria, an intriguing relationship.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International review of cell and molecular biology - 01 Jan 2023

García-Rodríguez FJ, Buchrieser C, Escoll P,

Link to Pubmed [PMID] – 36858656

Link to DOI – 10.1016/bs.ircmb.2022.10.001S1937-6448(22)00135-6

Int Rev Cell Mol Biol 2023 ; 374(): 37-81

Legionella pneumophila is the causative agent of Legionnaires’ disease, a severe pneumonia. L. pneumophila injects via a type-IV-secretion-system (T4SS) more than 300 bacterial proteins into macrophages, its main host cell in humans. Certain of these bacterial effectors target organelles in the infected cell and hijack multiple processes to facilitate all steps of the intracellular life cycle of this pathogen. In this review, we discuss the interplay between L. pneumophila, an intracellular bacterium fully armed with virulence tools, and mitochondria, the extraordinary eukaryotic organelles playing prominent roles in cellular bioenergetics, cell-autonomous immunity and cell death. We present and discuss key findings concerning the multiple interactions of L. pneumophila with mitochondria during infection and the mechanisms employed by T4SS effectors that target mitochondrial functions to subvert infected cells.