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  • Director of Center
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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : Nature reviews. Microbiology

Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Microbiology - 01 Jan 2016

Escoll P, Mondino S, Rolando M, Buchrieser C

Link to Pubmed [PMID] – 26594043

Nat. Rev. Microbiol. 2016 Jan;14(1):5-19

Many bacterial pathogens have evolved the ability to subvert and exploit host functions in order to enter and replicate in eukaryotic cells. For example, bacteria have developed specific mechanisms to target eukaryotic organelles such as the nucleus, the mitochondria, the endoplasmic reticulum and the Golgi apparatus. In this Review, we highlight the most recent advances in our understanding of the mechanisms that bacterial pathogens use to target these organelles. We also discuss how these strategies allow bacteria to manipulate host functions and to ultimately enable bacterial infection.