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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : Current topics in microbiology and immunology

From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current topics in microbiology and immunology - 01 Jan 2013

Escoll P, Rolando M, Gomez-Valero L, Buchrieser C

Link to Pubmed [PMID] – 23949285

Curr. Top. Microbiol. Immunol. 2013;376:1-34

Legionella pneumophila is a Gram-negative bacterium and the causative agent of Legionnaires’ disease. It replicates within amoeba and infects accidentally human macrophages. Several similarities are seen in the L. pneumophila-infection cycle in both hosts, suggesting that the tools necessary for macrophage infection may have evolved during co-evolution of L. pneumophila and amoeba. The establishment of the Legionella-containing vacuole (LCV) within the host cytoplasm requires the remodeling of the LCV surface and the hijacking of vesicles and organelles. Then L. pneumophila replicates in a safe intracellular niche in amoeba and macrophages. In this review we will summarize the existing knowledge of the L. pneumophila infection cycle in both hosts at the molecular level and compare the factors involved within amoeba and macrophages. This knowledge will be discussed in the light of recent findings from the Acanthamoeba castellanii genome analyses suggesting the existence of a primitive immune-like system in amoeba.

http://www.ncbi.nlm.nih.gov/pubmed/23949285