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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : The Journal of infectious diseases

Legionella longbeachae is immunologically silent and highly virulent in vivo

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 08 Dec 2016

Massis LM, Assis-Marques MA, Castanheira FV, Capobianco YJ, Balestra AC, Escoll P, Wood RE, Manin GZ, Correa VM, Alves-Filho JC, Cunha FQ, Buchrieser C, Borges MC, Newton HJ, Zamboni DS

Link to Pubmed [PMID] – 27932612

J. Infect. Dis. 2016 Dec;

BACKGROUND: Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumonia-causing agents of the genus. Although both species can be lethal to humans and are highly prevalent, little is known about the molecular pathogenesis of Llo infections. In murine models of infection, Lpn infection is self-limited whereas Llo infection is lethal.

DESIGN/METHODS: We used mouse macrophages, human macrophages, human epithelial cells and mouse infections in vivo to evaluate multiple parameters of the infection.

RESULTS: We determined that the Llo Dot/Icm secretion system is critical for virulence. Different than Lpn, Llo disseminates and the animals develop a severe pulmonary failure, as demonstrated by lung mechanics and blood oxygenation assays. As compared to Lpn, Llo is immunologically silent and fails to trigger the production of cytokines in human pulmonary epithelial cells and in mouse and human macrophages. Infections in Tnfr1(-/-) , Ifng(-/-) and Il12p40(-/-) mice supported the participation of cytokines for the resistance phenotype.

CONCLUSIONS: Both Lpn and Llo require the Dot/Icm system for pathogenesis, but the infection outcome is strikingly different. Llo is immunologically silent, highly virulent and lethal. The differences reported herein may reflect unappreciated clinical differences in patients infected with Lpn or Llo.

https://www.ncbi.nlm.nih.gov/pubmed/27932612